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  • Teresa Fernandes-Alnemri, Gerald Litwack, Emad S. Alnemri
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1994 (First Publication: 9 December 1994)
  • We have cloned a novel apoptotic gene from human Jurkat T-lymphocytes. The new gene encodes a 32-kDa putative cysteine protease (CPP32) with significant homology to Caenorhabditis elegans cell deathExpand
  • Teresa Fernandes-Alnemri, Robert C. Armstrong, +8 authors Emad S. Alnemri
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 23 July 1996)
  • Emerging evidence suggests that an amplifiable protease cascade consisting of multiple aspartate specific cysteine proteases (ASCPs) is responsible for the apoptotic changes observed in mammalianExpand
  • Manzoor Ahmad, Srinivasa M Srinivasula, Lin Lin Wang, Gerald Litwack, Teresa Fernandes-Alnemri, Emad S. Alnemri
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1997 (First Publication: 17 January 1997)
  • Employing the degenerate primer-dependent polymerase chain reaction approach used recently to clone human Mch2, we have identified and cloned the insect Spodoptera frugiperda target of theExpand
  • Srinivasa M Srinivasula, Manzoor Ahmad, Teresa Fernandes-Alnemri, Gerald Litwack, Emad S. Alnemri
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 10 December 1996)
  • The Fas/APO-1-receptor associated cysteine protease Mch5 (MACH/FLICE) is believed to be the enzyme responsible for activating a protease cascade after Fas-receptor ligation, leading to cell death.Expand
  • Aya Takahashi, Emad S. Alnemri, +7 authors William C Earnshaw
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 6 August 1996)
  • Although proteases related to the interleukin 1 beta-converting enzyme (ICE) are known to be essential for apoptotic execution, the number of enzymes involved, their substrate specificities, andExpand
  • Srinivasa M Srinivasula, Teresa Fernandes-Alnemri, +7 authors Emad S. Alnemri
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1996 (First Publication: 25 October 1996)
  • Recent evidence suggests that CPP32 is an essential component of an aspartate-specific cysteine protease (ASCP) cascade responsible for apoptosis execution in mammalian cells. Activation of CPP32Expand