Gerald Löffler

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Human cancer is characterized by complex molecular perturbations leading to variable clinical behavior, often even in single-disease entities. We performed a feasibility study systematically comparing large-scale gene expression profiles with clinical features in human B-cell chronic lymphocytic leukemia (B-CLL). cDNA microarrays were employed to determine(More)
Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal hormone with immunomodulatory effects such as inhibition of the production of monokines. Whether DHEA itself or the downstream steroids are the immunomodulatory effector hormones in target cells is not known. In this study, we investigated the conversion of DHEA to downstream steroid hormones in target(More)
Aromatization of circulating androgens in adipose tissue is a major source of estrogens in postmenopausal women. As part of our efforts to elucidate the mechanism of aromatase induction in human breast adipose tissue, we tested the effects of the antiglucocorticoid and antiprogestin, RU486, on aromatase induction in primary cultures of adipose tissue(More)
1 Motivation Our research in theoretical biophysics [6] recently required us to solve a variant of the Poisson equation, which is a linear elliptic partial differential equation (PDE) in 3D. Ultimately, we want to make our method available as a applet, so we decided to implement a PDE solver in Java. Another reason for using Java was its promise of easy,(More)
The essential goal of this work is the unified treatment of quantum mechanical and classical degrees of freedom in biomolecular simulation on all three levels: Theory, algorithms and implementation. In theory this is done within the framework of the Lagrangian model, which handles electronic coordinates and Cartesian nuclear coordinates in a consistent way.(More)
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