Gerald J. Clesham | Semantic Scholar

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Expression of endoglin mRNA and protein in human vascular smooth muscle cells.

Paul J. Adam, Gerald J. Clesham, Peter L. Weissberg
Biochemical and biophysical research…
1998

Endoglin, the gene linked to the autosomal dominant vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1), encodes a 95-kDa membrane-bound proteoglycan which binds TGF beta 1 and… (More)

Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST-Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design

Heerajnarain Bulluck, Georg Marcus Fröhlich, +20 authors Derek Hausenloy
Clinical cardiology
2015

Novel therapies capable of reducing myocardial infarct (MI) size when administered prior to reperfusion are required to prevent the onset of heart failure in ST-segment elevation myocardial… (More)

Is vascular smooth muscle cell proliferation beneficial?

Peter L. Weissberg, Gerald J. Clesham, Michael R Bennett
The Lancet
1996

Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cells.

Gerald J. Clesham, Helena M Browne, Stacey Efstathiou, Peter L. Weissberg
Circulation research
1996

Recombinant adenoviral vectors are being used increasingly for gene transfer studies in mammalian cells and gene therapy protocols in humans. High adenoviral titers are often required for successful… (More)

Survey of the use of epinephrine (adrenaline) for anaphylaxis by junior hospital doctors.

Ricardo Jorge Paixão José, Gerald J. Clesham
Postgraduate medical journal
2007

BACKGROUND Anaphylaxis is a life threatening reaction where prompt and appropriate management can save lives. Epinephrine (adrenaline) is the treatment of choice; however, the recommended dose and… (More)

Impact of a chronic total occlusion in a non-infarct related artery on clinical outcomes following primary percutaneous intervention in acute ST-elevation myocardial infarction.

Abdul M. Mozid, Shah Mohdnazri, +9 authors John R. Davies
The Journal of invasive cardiology
2014

AIMS We aimed to assess the impact of a non-infarct related artery (IRA) chronic total occlusion (CTO) on clinical outcomes following primary percutaneous coronary intervention (PPCI) for… (More)

Typical takotsubo cardiomyopathy in suspected ST elevation myocardial infarction patients admitted for primary percutaneous coronary intervention.

Refai Showkathali, Hetalkumar Patel, +5 authors Paul Kelly
European journal of internal medicine
2014

AIM Takotsubo cardiomyopathy (TCM) is increasingly being recognised in patients admitted with suspected acute coronary syndrome, as access to angiography and echocardiography is much quicker than… (More)

Identification and characterisation of transforming growth factor beta-regulated vascular smooth muscle cell genes.

Paul J. Adam, Gerald J. Clesham, P D Flynn, Peter L. Weissberg
Cytokine
2000

Transforming growth factor beta (TGFbeta) is thought to play an important role in the development and/or progression of a number of vascular disorders through its numerous effects on vascular smooth… (More)

Clinical implications of ST-segment non-resolution after thrombolysis for myocardial infarction.

Lav Bhatia, Gerald J. Clesham, Douglas R. Turner
Journal of the Royal Society of Medicine
2004

Failed reperfusion after thrombolytic therapy for acute myocardial infarction is common and signifies a poor prognosis. We investigated the clinical consequences of non-resolution of the ST segment… (More)

Echocardiographic assessment of cardiac involvement in systemic AL amyloidosis in relation to whole body amyloid load measured by serum amyloid P component (SAP) clearance.

Gerald J. Clesham, David M. Vigushin, Philip N. Hawkins, Mark B Pepys, Celia M. Oakley, Petros Nihoyannopoulos
The American journal of cardiology
1997

The severity of cardiac infiltration in AL amyloidosis is unrelated to whole body amyloid load as measured by serum amyloid P (SAP) tracer studies. Radiolabeled SAP and echocardiography permit… (More)