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  • C. Yu, Y. Chen, +11 authors G. Shulman
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 27 December 2002)
  • Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositolExpand
  • Kitt F Petersen, Sylvie Dufour, Douglas E. Befroy, Rina Garcia, Gerald I. Shulman
  • Medicine
  • The New England journal of medicine
  • 2004 (First Publication: 12 February 2004)
  • BACKGROUND Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown. METHODS WeExpand
  • Haihong Zong, J. M. Ren, +4 authors Gerald I. Shulman
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 20 November 2002)
  • Mitochondrial biogenesis is a critical adaptation to chronic energy deprivation, yet the signaling mechanisms responsible for this response are poorly understood. To examine the role of AMP-activatedExpand