Gerald G. Fuller

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Meibum is the primary component of the tear film lipid layer. Thought to play a role in tear film stabilization, understanding the physical properties of meibum and how they change with disease will be valuable in identifying dry eye treatment targets. Grazing incidence X-ray diffraction and X-ray reflectivity were applied to meibum films at an air-water(More)
The phenomenon of dewetting is frequently observed in our everyday life. It is of central importance in many technological applications as well as in a variety of physical and biological systems. The presence of nonsoluble surfactants at an air/liquid interface may affect the dewetting properties of the aqueous layer. An important example is the tear film,(More)
We report a straightforward, bottom-up, scalable process for preparing mineralized nanofibers. Our procedure is based on flowing feed solution, containing both inorganic cations and polymeric molecules, through a nanoporous membrane into a receiver solution with anions, which leads to the formation of mineralized nanofibers at the exit of the pores. With(More)
In patients with severe to profound hearing loss, cochlear implants (CIs) are currently the only therapeutic option when the amplification with conventional hearing aids does no longer lead to a useful hearing experience. Despite its great success, there are patients in which benefit from these devices is rather limited. One reason may be a poor(More)
Vascular anastomosis is the cornerstone of vascular, cardiovascular and transplant surgery. Most anastomoses are performed with sutures, which are technically challenging and can lead to failure from intimal hyperplasia and foreign body reaction. Numerous alternatives to sutures have been proposed, but none has proven superior, particularly in small or(More)
Alzheimer's disease is the most common cause of dementia and is widely believed to be due to the accumulation of beta-amyloid peptides (Abeta) and their interaction with the cell membrane. Abetas are hydrophobic peptides derived from the amyloid precursor proteins by proteolytic cleavage. After cleavage, these peptides are involved in a(More)
Langmuir monolayers of mixtures of straight-chain and branched molecules of hexadecanol and eicosanol were studied using surface pressure-area isotherms, Brewster angle microscopy, and interfacial rheology measurements. For hexadecanol mixtures below 30% branched molecules, the isotherms show a lateral shift to a decreasing area proportional to the fraction(More)
The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Abeta-induced degeneration and synaptic dysfunction. These ligands inhibited Abeta-induced neuritic dystrophy, death(More)
Langmuir monolayers of straight-chain and branched hexadecanol and eicosanol mixtures were previously studied using surface pressure- area isotherms, Brewster angle microscopy, and interfacial rheology. In this paper, we investigate the structure of these fatty alcohol mixtures using these previous results together with X-ray diffraction and reflectivity(More)
As the interface between the aqueous layer of the tear film and air, the lipid layer plays a large role in maintaining tear film stability. Meibomian lipids are the primary component of the lipid layer; therefore the physical properties of these materials may be particularly crucial to the functionality of the tear film. Surface pressure versus area(More)