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The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Abeta-induced degeneration and synaptic dysfunction. These ligands inhibited Abeta-induced neuritic dystrophy, death(More)
The p75 neurotrophin receptor (p75 NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75 NTR ligands found to promote survival signaling might prevent Ab-induced degeneration and synaptic dysfunction. These ligands inhibited Ab-induced neuritic dystrophy, death of(More)
The p75 neurotrophin receptor (p75 NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75 NTR ligands found to promote survival signaling might prevent Ab-induced degeneration and synaptic dysfunction. These ligands inhibited Ab-induced neuritic dystrophy, death of(More)
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