Gerald D Robinson

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Positron emission tomographic studies of 16 patients with cerebral ischemia and brain tumor showed asymmetries in cerebellar metabolism not encountered in 14 normal control subjects. An asymmetry was present in 62.5% of cases. The lower metabolic rate occurred in the cerebellar hemisphere contralateral to the cerebral lesion (p less than 0.001; sign test).(More)
This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O. A whole-brain CBF model is described that permits the comparison of the CBF values determined using PET with those obtained using other methods. This model includes a correction(More)
123I-hexadecenoic acid is a terminally iodinated, 17-carbon fatty acid analog which is rapidly degraded in the myocardium. By determining regional myocardial distribution patterns and clearance rates, it may become useful as a single agent for estimating regional myocardial perfusion and for distinguished viable ischemic tissue from infarcted tissue. The(More)
Progress in myocardial perfusion imaging has been slowed by the lack or radiopharmaceuticals with suitable physical and biologic characteristics. Hexadecenoic acid, terminally labeled with 123I, partially overcomes these limitations by providing a compound that concentrates in the myocardium in proportion to relative regional blood flow and carries a(More)
Radioiodinated fatty acids have been proposed as agents for use in heart imaging. Previous studies in experimental animals and humans using 131I-oleic acid of low specific activity were marginally successful. Higher specific activity compounds offer potential improvement for use as imaging agents for normal myocardium. Methods for preparation of high(More)
SUMMARY The potential of positron-emission computed tomography (PCT) for external quantitation of myocardial indicator concentrations and regional myocardial blood flow (RMBF) and the effect of left ventric-ular wall thickness on tracer concentration recovery by PCT was examined in seven open-chest dogs. RMBF was determined by the arterial reference(More)