Gerald A. Poore

Publications37
h-index16
Citations1,804
Highly Influential Citations23
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Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).
A new pyrimidine antimetabolite, 2',2'-difluorodeoxycytidine, Gemcitabine (LY188011, dFdCyd) has been synthesized and evaluated in experimental tumor models. dFdCyd is a very potent and specific… Expand
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Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships.
A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo… Expand
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Tumor remission in Yoshida sarcoma-bearing rts by selective targeting of magnetic albumin microspheres containing doxorubicin.
Magnetically responsive albumin microspheres containing doxorubicin and magnetite (Fe3O4) were selectively targeted to Yoshida sarcoma tumors in rats by utilizing an extracorporeal magnet. Tumor… Expand
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Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: total remission in Yoshida sarcoma-bearing rats.
Magnetically responsive albumin microspheres containing doxorubicin hydrochloride were selectively localized in Yoshida sarcoma tumors. Tumors were implanted subcutaneously in the tail of Holtzman… Expand
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Alkaloids of Acronychia Baueri Schott I. Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine.
Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott ( Bauerella australiana Borzi), has resulted in the isolation of the… Expand
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Possible in Situ Activation of Mycophenolic Acid by β-Glucuronidase
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Experimental antitumor activity and preclinical toxicology of mycophenolic acid.
Summary Mycophenolic acid completely inhibited the growth of the Mecca lymphosarcoma and of the solid and ascites forms of Walker carcinosarcoma 256. The Gardner lymphosarcoma, C3H mammary carcinoma,… Expand
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Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates.
While structure-activity relationships for vinblastine (VLB), vincristine, deacetyl-VLB, and deacetyl-VLB amide (vindesine, VDS) in several tumor and leukemia models have been reported previously,… Expand
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Acetylenic carbamates. A new class of potential oncolytic agents.
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Novel Agents Effective Against Solid Tumors: The Diarylsulfonylureas. Synthesis, Activities, and Analysis of Quantitative Structure‐Activity Relationships.
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