Geraint Fuller

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The members of the mitogen-activated protein (MAP) kinase family -- p44/p42 MAP kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAP kinase (p38) are known to be important mediators of the physiological plasticity or neurotoxicity induced in the striatum by activation of ionotropic glutamate receptors. However, our knowledge of the class of glutamate(More)
For the full versions of these articles see bmj.com Trigeminal neuralgia is a severe unilateral paroxys-mal facial pain, often described by patients as the " the world's worst pain. " Data sources and selection criteria We searched Medline, National Institute for Health and Clinical Excellence (NICE), and Cochrane databases using the terms " trigeminal(More)
The transcription factor NF-kappaB has been implicated in the synaptic plasticity and neurotoxicity mediated by ionotropic glutamate receptors in the striatum. However, the class of glutamate receptor and the intracellular pathways involved have not been determined. Kainate, but not AMPA or NMDA, was found to activate NF-kappaB in superfused slices of rat(More)