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- Pieter P. de Tombe, Ger J M Stienen
- Circulation research
- 1995
Recent mechanical, biochemical, and energetic experiments have suggested that catecholamines may increase the cycling rate of cross-bridges independent of changes inn intracellular calcium. An… (More)
- Ger J M Stienen, Jeroen L Kiers, Roberto Bottinelli, Carlo Reggiani
- The Journal of physiology
- 1996
1. Myofibrillar ATP consumption and isometric tension (P0) were determined in chemically skinned skeletal muscle fibres from human rectus abdominis and vastus lateralis muscle. Fibres were classified… (More)
- Roberto Bottinelli, Monica Canepari, Carlo Reggiani, Ger J M Stienen
- The Journal of physiology
- 1994
1. Myofibrillar ATPase activity, isometric tension (Po) and unloaded shortening velocity (Vo) were determined in single skinned fibres isolated from rat hindlimb muscles during maximal calcium… (More)
- Ger J M Stienen, Ruud Zaremba, Gijs Elzinga
- The Journal of physiology
- 1995
1. A method has been developed to discriminate between the rate of ATP hydrolysis associated with calcium uptake into the sarcoplasmic reticulum (SR) and force development of the contractile… (More)
- Loek van Heerebeek, Attila Borbély, +6 authors Walter Paulus
- Circulation
- 2006
BACKGROUND
To support the clinical distinction between systolic heart failure (SHF) and diastolic heart failure (DHF), left ventricular (LV) myocardial structure and function were compared in LV… (More)
- Silvia Rain, Martin Louis Handoko, +18 authors Frances S. de Man
- Circulation
- 2013
BACKGROUND
The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying… (More)
- Coen A. C. Ottenheijm, Christian C. Witt, Ger J M Stienen, Siegfried Labeit, Alan H. Beggs, Henk L. M. Granzier
- Human molecular genetics
- 2009
Nemaline myopathy (NM) is the most common non-dystrophic congenital myopathy. Clinically the most important feature of NM is muscle weakness; however, the mechanisms underlying this weakness are… (More)
- Loek van Heerebeek, Nazha Hamdani, +13 authors Walter Paulus
- Circulation
- 2008
BACKGROUND
Excessive diastolic left ventricular stiffness is an important contributor to heart failure in patients with diabetes mellitus. Diabetes is presumed to increase stiffness through… (More)
- Jolanda van der Velden, Zoltán Papp, +7 authors Ger J M Stienen
- Cardiovascular research
- 2003
OBJECTIVE
The alterations in contractile proteins underlying enhanced Ca(2+)-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved. In the present… (More)
- Vasco Sequeira, Paul J. M. Wijnker, +19 authors Jolanda van der Velden
- Circulation research
- 2013
RATIONALE
High-myofilament Ca(2+) sensitivity has been proposed as a trigger of disease pathogenesis in familial hypertrophic cardiomyopathy (HCM) on the basis of in vitro and transgenic mice… (More)