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Alloferons are a group of naturally occurring peptides primarily isolated from insects that are capable of stimulating mouse and human NK cell cytotoxicity toward cancer cells. In this study, we found that a modified antibacterial peptide had a broad range of action against both gram-positive and gram-negative bacteria. A time-course experiment showed that(More)
PURPOSE Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. Exosomes or extracellular vesicles are nanosized vesicles of endosomal origin released from inflammatory and epithelial cells that have been implicated in allergic diseases. In this study, we characterized the microRNA (miRNA) content of exosomes in AR. METHODS Extracellular(More)
OBJECTIVE To study the significance and effect of SP on the expression of RANTES mRNA in allergic rhinitis (AR), and deeply understand the pathogenesis of AR. METHOD The model of AR was established in randomly selected healthy guinea pigs by using ovalbumin. Then the nasal dripping of SP was used to challenge the AR groups, as compared with the normal(More)
Embryonic stem cells (ESCs) are key tools for genetic engineering and development of stem cell-based therapies. The investigation of ESCs pluripotency and early lineage commitment is an essential precondition for its translational use. In this study, we explored the ability of mouse ESC to differentiate into inner ear hair cell lineages. Mouse embryonic(More)
OBJECTIVE To study the mechanism of recombination activating gene-1 in pathogenesis of allergic rhinitis and its relation to interleukin-4 (IL-4), interleukin-10 (IL-10) and immunoglobin E (IgE). METHOD Three groups of allergic rats models were established with ovalbumin (OVA) and intervened with Dexamethasone (DEX). The times of sneeze were recorded, the(More)
OBJECTIVE To explore the expression of Eotaxin and the effect of histamine in allergic rhinitis model (AR), and aim to explore the pathogenesis of AR. METHOD The AR models were established by application of ovum albumin in rats. The expression of Eotaxin in nasal mucosa, serum and nasal cavity lavage fluid, were observed before and after treatment of(More)
OBJECTIVE To study the change of endogenous hydrogen sulfide (hydrogen sulfide, H2S) and its rate-limiting enzyme Cystathionine-gamma-lyase (CSE) in allergic rhinitis through guinea pigs with intervention treatment. METHOD Twenty-four guinea pigs were divide into 4 groups at random, one group were models of allergic rhinitis (AR) which were established by(More)
Nuclear factor erythroid-2-related factor 2(Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) signaling pathway is abnormally activated in response to cellular stress in various types of human cancers. In this study, we examined the immunohistochemical expression of nuclear Nrf2 and cytoplasmic Keap1 in 108 nasopharyngeal carcinoma (NPC) tissue specimens(More)
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