Georgios Ismailos

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BACKGROUND The degree of penetration of clarithromycin into the pleural fluid has not been studied. OBJECTIVE To determine the degree to which clarithromycin penetrates into empyemic pleural fluid using a new rabbit model of empyema. METHODS An empyema was created via the intrapleural injection of 1 ml turpentine followed 24 h later by instillation of 5(More)
To determine the extent of linezolid and ertapenem penetration into the empyemic fluid using a rabbit model of empyema. An empyema was created via the intrapleural injection of Escherichia coli bacteria (ATCC 35218) into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracocentesis, 24 hours post inoculation, linezolid (10(More)
OBJECTIVE To investigate the effect of gestation on the pharmacokinetics of orally administered beta-lactams, choosing cefatrizine as the model antibiotic. SETTING A tertiary teaching hospital. DESIGN Prospective study. METHODS In 20 women with affected fetuses, 17 by beta-thalassemia major and 3 with congenital malformations, termination of gestation(More)
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