Georgia Theocharopoulou

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Recent biomedical research studies are focused in the mechanisms by which misfolded proteins lead to the generation of oxidative stress in the form of reactive oxygen species (ROS), often implicated in neurodegenerative diseases and aging. Moreover, biological experiments are designed to investigate how proteostasis depends on the balance between the(More)
Programmed death-ligand 1 (PD-L1) has been speculated to play a critical role in suppression of the immune system and it can be upregulated in cancer cells, which may allow cancers to evade the host immune system. MicroRNAs (miRNAs) are small non-coding RNA molecules (containing about 22 nucleotides), that function in RNA silencing and post-transcriptional(More)
The diagnosis of inherited peripheral neuropathies can be a challenging issue in several ways. Current research is focused on a multidisciplinary approach, developing new therapeutic strategies mainly involving online databases and repositories for sharing data and models used in some clinical trials. In this paper authors introduce the general architecture(More)
Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder. Recent advancements in molecular biology have elucidated the molecular bases of this genetically heterogeneous neuropathy. Still, the major challenge lies in determining the individual contributions by malfunctions of proteins to the disease's pathology. This paper(More)
Bio-inspired models of computation are systems influenced by the functioning of biological systems. The mitochondrial membrane structure contains two distinct compartments separated by membranes, which act as separators and as channels of communication between compartments. Mitochondria have been observed to go through frequent fusion and fission. The(More)
Oxidative stress is a metabolic condition generating from the disproportion between the production of potentially reactive oxygen species and the scavenging activities. Increased level of reactive oxygen species may cause increased oxidative damage of biomolecules, an accumulation of this damage, and the development of many pathogenic conditions, especially(More)
Stress and misfolded proteins result to dysfunction in the cell, often leading to neurodegenerative diseases and aging. Misfolded proteins form toxic aggregates that threaten cell's stability and normal functions. In order to restore its homeostasis, the cell activates the UPR system. Leading role in the restoration play the molecular chaperones which(More)
In this study, the goal is multifold. At first we present a summarized review of terms and facts regarding the branch of ecoinformatics, web mining and the semantic web. In Section 2 we provide some related work derived from the current literature upon the web mining and the production of semantic content. The main part of our work follows presenting a(More)
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