Georgia Minakaki

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α-Synuclein is readily released in human and mouse brain parenchyma, even though the normal function of the secreted protein has not been yet elucidated. Under pathological conditions, such as in Parkinson's disease, pathologically relevant species of α-synuclein have been shown to propagate between neurons in a prion-like manner, although the mechanism by(More)
The glutamate transporter xCT (SCL7a11, system Xc-, SXC) is an emerging key player in glutamate/cysteine/glutathione homeostasis in the brain and in cancer. xCT expression correlates with the grade of malignancy. Here, we report on the use of the U.S. Food and Drug Administration and EMA-approved xCT inhibitor, sulfasalazine (SAS) in gliomas. SAS does not(More)
Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson's disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, we addressed the impact of aSyn specifically on mitochondrial response to OS in neural cells. We characterize a distinct(More)
OBJECTIVE Mutations in the Spastic Paraplegia Gene11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal recessive (AR) complex hereditary spastic paraplegia (HSP) and juvenile onset amyotrophic lateral sclerosis (ALS5). When SPG11 is mutated, patients frequently present with spastic paraparesis, a thin corpus callosum, and cognitive(More)
Himanshu K. Mishra, PhD, Iryna Prots, PhD, Steven Havlicek, PhD, Zacharias Kohl, MD, Francesc Perez-Branguli, PhD, Tom Boerstler, BSc, Lukas Anneser, MSc, Georgia Minakaki, MSc, Holger Wend, Martin Hampl, MSc, Marina Leone, PhD, Martina Br€ uckner, Jochen Klucken, MD, Andre Reis, MD, Leah Boyer, PhD, Gerhard Schuierer, MD, J€ urgen Behrens, PhD, Angelika(More)
1.1 α-synuclein: A “leading act” in the synapse α-Synuclein is a relatively abundant 140-residue neuronal protein physiologically found in presynaptic neuronal terminals (Abeliovich et al., 2000; Spillantini, Crowther, Jakes, Hasegawa, & Goedert, 1998; Wacker, Zareie, Fong, Sarikaya, & Muchowski, 2004). αsynuclein belongs to a highly conserved family of(More)
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