Georgi Minchev

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BACKGROUND Because of intratumoral heterogeneity, diffusely infiltrating gliomas that lack significant contrast enhancement on magnetic resonance imaging are prone to tissue sampling error. Subsequent histologic undergrading may delay adjuvant treatments. 5-Aminolevulinic acid (5-ALA) leads to accumulation of fluorescent porphyrins in malignant glioma(More)
OBJECTIVE In diffusely infiltrating gliomas (DIG), positron emission tomography (PET) imaging is a powerful method for detection of anaplastic foci. Recently, (1)H-magnetic resonance spectroscopy chemical shift imaging (CSI) using choline/creatine (Cho/Cr) or choline/N-acetylaspartate (Cho/NAA) ratios has emerged as a new non-invasive, widely available(More)
Fractal analysis is widely applied to investigate the vascular system in physiological as well as pathological states. We propose and examine a computer-aided and fractal-based image analysis technique to quantify the microvascularity in histological specimens of WHO grade II and III gliomas. A computer-aided and fractal-based analysis was used to describe(More)
Stereotactic biopsies represent a routine neurosurgical procedure for the diagnosis of intracranial lymphomas and selected diffusely infiltrating gliomas. Acquisition of tissue samples that do not allow correct tumor typing and grading is, however, not uncommon. Five-aminolevulinic acid (5-ALA) has been shown to accumulate in malignant tumor tissue. The aim(More)
OBJECT Surgery of suspected low-grade gliomas (LGGs) poses a special challenge for neurosurgeons due to their diffusely infiltrative growth and histopathological heterogeneity. Consequently, neuronavigation with multimodality imaging data, such as structural and metabolic data, fiber tracking, and 3D brain visualization, has been proposed to optimize(More)
OBJECTIVE The authors' group recently published a novel technique for a navigation-guided frameless stereotactic approach for the placement of depth electrodes in epilepsy patients. To improve the accuracy of the trajectory and enhance the procedural workflow, the authors implemented the iSys1 miniature robotic device in the present study into this routine.(More)
OBJECTIVE Robotic devices have recently been introduced in stereotactic neurosurgery in order to overcome the limitations of frame-based and frameless techniques in terms of accuracy and safety. The aim of this study is to evaluate the feasibility and accuracy of the novel, miniature, iSYS1 robotic guidance device in stereotactic neurosurgery. METHODS A(More)
Phase-shifting profilometry requires projection of sinusoidal fringes on a 3D object. We analyze the visibility and frequency content of fringes created by a sinusoidal phase grating at coherent illumination. We derive an expression for the intensity of fringes in the Fresnel zone and measure their visibility and frequency content for a grating that has(More)
Submillimetric precision is essential for stereotactic neurosurgical procedures. However, accuracy of standard neurosurgical procedures such as navigated biopsies and shunts is currently limited due to manual alignment of the biopsy needle or manual placement of the shunt catheter. The aim of this study is to evaluate the feasibility and accuracy of a novel(More)
Basic holographic characteristics of a newly developed panchromatic ultrafine grain silver halide light sensitive material for RGB recording of reflective holographic screen for autostereoscopic 3D display are presented. The average grain size is less than 10 nm which ensures high resolution, diffraction efficiency, and signal-to-noise ratio (more than 100(More)
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