Georgi K. Kanev

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Protein kinases play a crucial role in cell signaling and are important drug targets in several therapeutic areas. The KLIFS database contains detailed structural kinase-ligand interaction information derived from all (>2900) structures of catalytic domains of human and mouse protein kinases deposited in the Protein Data Bank in order to provide insights(More)
A systematic analysis is presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Protein Data Bank (PDB) with a focus on PDE-ligand interactions. The consistent structural alignment of 57 PDE ligand binding site residues enables the systematic analysis of PDE-ligand interaction fingerprints (IFPs), the identification(More)
Clarifying of geoecological aspects of nature use is one of the most important criteria for sustainable development assessment of the territory. This is a comparatively new trend in nature sciences. The report represents a model for organization of geodatabase for purposes of large-scale mapping of land-use conflicts for mapping level of the land of(More)
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