Georgette De Jesus

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BACKGROUND A large body of evidence suggests that immune system dysregulation is associated with Major Depressive Disorder (MDD) in adults. This study extends this work to adolescent MDD to examine the hypotheses of immune system dysregulation in adolescents with MDD, as manifested by significantly: (i) elevated plasma levels of cytokines (interferon(More)
BACKGROUND Preclinical and clinical evidence indicate that the glutamatergic system might play a role in the pathophysiology of mood disorders. This study was conducted to determine the efficacy and safety of riluzole, a glutamate-modulating agent, in bipolar depression. METHODS This was an 8-week add-on study of riluzole in combination with lithium in(More)
OBJECTIVE This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary(More)
Same day surgery patients have unique needs, distinct from those of traditional long-stay inpatients and outpatients. Their postoperative needs at home are central to achieving complete recovery and ensuring there are no unplanned readmissions to hospital. In a quality improvement project at Royal Perth Hospital, a patient satisfaction questionnaire survey(More)
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