George W. Fuller

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The pathologic picture in ischemic tissue injury shares features with the inflammatory response, including production of proinflammatory cytokines. Hypoxia-mediated induction of interleukin-6 (IL-6), a cytokine with anti-inflammatory properties, could set in motion mechanisms limiting inflammation in ischemia. Exposure of cultured endothelial cells (ECs) to(More)
The members of the mitogen-activated protein (MAP) kinase family -- p44/p42 MAP kinase (ERK), c-jun N-terminal kinase (JNK) and p38 MAP kinase (p38) are known to be important mediators of the physiological plasticity or neurotoxicity induced in the striatum by activation of ionotropic glutamate receptors. However, our knowledge of the class of glutamate(More)
Two mouse monoclonal IgG2b antibodies that differ in their CH2 domains have been compared for their blood mean residence times (MRTs) in normal female Rhesus monkeys. A biosynthetically incorporated radiolabel (S-35 methionine) was used to follow blood elimination of the antibodies and urinary excretion. Results indicate that the blood (plasma) MRTs for the(More)
This article describes the working relationship between the administration and medical staff of the Mid-Maine Medical Center which is comprised of two separate modern hospitals. The authors advocate the philosophy that "a hospital which harnesses the medical staff's considerable talent and expertise through sound organizational input will be a stronger(More)
The transcription factor NF-kappaB has been implicated in the synaptic plasticity and neurotoxicity mediated by ionotropic glutamate receptors in the striatum. However, the class of glutamate receptor and the intracellular pathways involved have not been determined. Kainate, but not AMPA or NMDA, was found to activate NF-kappaB in superfused slices of rat(More)
While vehicle emissions present the most widespread cause of breaches of EU air quality standards in urban areas of the UK, the greatest PM10 concentrations are often recorded close to small industrial sites with significant and long-term public exposure within close proximity. This is particularly the case in London, where monitoring in densely populated(More)