George W. Fryhofer

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The Achilles tendon is the most commonly ruptured tendon in the human body. Numerous studies have reported incidence of these injuries to be upwards of five times as common in men than women. Therefore, the objective of this study was to investigate the sex- and hormone-specific differences between Achilles tendon and muscle between female, ovariectomized(More)
Achilles tendon ruptures are common injuries. Sex differences are present in mechanical properties of uninjured Achilles tendon, but it remains unknown if these differences extend to tendon healing. We hypothesized that ovariectomized females (OVX) and males would exhibit inferior postinjury tendon properties compared with females. Male, female, and OVX(More)
INTRODUCTION Achilles tendon ruptures affect 15 of 100,000 women and 55 of 100,000 men each year. Controversy continues to exist regarding optimal treatment and rehabilitation protocols. The objective of this study was to investigate the temporal effects of surgical repair and immobilization or activity on Achilles tendon healing and limb function after(More)
Hypercholesterolemia is a serious health problem that is associated not only with heart disease, but also tendon pathology. In high cholesterol environments (e.g. familial hyperlipidemia), lipids accumulate within the tendon extracellular matrix and form deposits called xanthomas. Lipid-related changes are known to affect several tendon mechanical(More)
Introduction Rotator cuff tears are common shoulder injuries that cause significant pain and often require surgical intervention and physical therapy. Reestablishment of normal shoulder kinematics is often difficult and relies on balancing the active muscle forces and passive contact forces between the glenoid and the humeral head. Previous studies have(More)
Conservative treatment (non-operative) of Achilles tendon ruptures is suggested to produce equivalent capacity for return to function; however, long term results and the role of return to activity (RTA) for this treatment paradigm remain unclear. Therefore, the objective of this study was to evaluate the long term response of conservatively treated Achilles(More)
27 for viscoelastic, quasi-static, and fatigue testing, as described. An additional set of tendons (n 6/group) was used for histological and immunohistochemical analyses. Sagittal sections (7 μm) were stained with Hematoxylin-Eosin (H&E) and Safranin-O and Fast Green (SAF-O). Additionally, the gastrocnemius/soleus muscle complex was harvested, sectioned(More)
PURPOSE In the setting of acute deep upper extremity infections, evidence is lacking to guide the decision whether to send atypical cultures (fungal and acid-fast-bacillus [AFB]) during surgical debridement, especially in the presence of purulent fluid that is commonly observed with typical bacterial infections. Our purpose was to determine the frequency of(More)
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