George W. Adamson

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A group of 39 structures with local anesthetic activity has been classified automatically by calculating similarity or dissimilarity coefficients between pairs of structure diagrams and applying cluster analysis to the results. The performance of a number of similarity and dissimilarity coefficients has been compared using the relationship between structure(More)
A method of substructural analysis for structure-property correlation of data sets including heterocyclic structures is described. Structural features allowing representation of occurrence and position of heteroatoms, ring fusions, and substituents are derived automatically from Wiswesser Line Notation representations. Structural feature sets of varying(More)
The rapid rise of multi-drug-resistant bacteria is a global healthcare crisis, and new antibiotics are urgently required, especially those with modes of action that have low-resistance potential. One promising lead is the liposaccharide antibiotic moenomycin that inhibits bacterial glycosyltransferases, which are essential for peptidoglycan polymerization,(More)
Fragment sets generated manually from Wiswesser Line Notation have been used to correlate the chemical structures of a group of 79 penicillins with their serum binding activity, using multiple regression analysis. Statistically significant correlations were found, with results in accordance with the generally accepted nature of the binding. Algorithmic(More)
Climate change has become a key environmental narrative of the 21st century. However, emphasis on the science of climate change has overshadowed studies focusing on human interpretations of climate history, of adaptation and resilience , and of explorations of the institutions and cultural coping strategies that may have helped people adapt to climate(More)
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