George V. Forester

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Hearts from 4 week-old weanling pigs were capable of continuous work output when perfused with Krebs-Henseleit buffer containing 11 mM glucose. Perfused hearts metabolized either glucose or fatty acids, but optimum work output was achieved by a combination of glucose plus physiological concentrations (0.1 mM) of either palmitate or erucate. Higher(More)
Peak isometric tension was measured in isolated rat papillary muscles at different external calcium levels. Rested state contraction (RSC) tension follows a sigmoid curve when plotted against external calcium concentration [Ca]0. Half maximum tension is given at [Ca]0=0.4 mM. Tension declines with increasing stimulation frequency at [Ca]0=2.5 mM. As [Ca]0(More)
The relative changes in myocardial blood flows within different parts of the heart were measured in anaesthetized thoracotomized dogs during and following effusive pericardial tamponade. Blood flows measured in a group of animals bled to the same arterial hypotensive levels served as experimental controls. The results demonstrate that regional myocardial(More)
The effects of ultrasound on the mechanical properties of isometrically contracting rat papillary muscle have been studied as a function of the intensity of the ultrasonic irradiation. Each muscle was subjected to irradiation at 1.1., 2.2, and 3.3 W/cm2 at a frequency of 2.3 MHz. Ultrasonic irradiation caused heating in the vicinity of the muscle; thus it(More)
A system has been developed to measure the effects of ultrasound on membrane electrical properties and muscle contractile parameters. A specially designed muscle bath was constructed. Measurement instrumentation for glass microelectrodes and an isometric force transducer were interfaced to a Gould transient recorder and a PDP 11/03 computer. Electrical and(More)
A fiber optic reflectometer, capable of monitoring physiological parameters in a high magnetic field without significant disturbance of either rf or static fields, is described. Both cardiac and respiration rates were monitored with this optical device while 31P NMR spectra of the liver of an anesthetized rat were acquired.
The effect of 1.0 MHz ultrasound at an intensity of 1.0 W/cm2 SATA on brain function of anaesthetized cats was assessed using Visual Evoked Potentials (VEPs). Ultrasound alone did not significantly modify the averaged VEP signals. However, acute hypoxia depressed the VEP response. When the brain was exposed to ultrasound during the hypoxic episode, the VEP(More)