George Tse Hwai Wong

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The key structural feature in Boceprevir, Merck's new drug treatment for hepatitis C, is the bicyclic [3.1.0]proline moiety "P2". During the discovery and development stages, the P2 fragment was produced by a classical resolution approach. As the drug candidate advanced through clinical trials and approached regulatory approval and commercialization,(More)
OBJECTIVES The InSync III study evaluated sequential cardiac resynchronization therapy (CRT) in patients with moderate-to-severe heart failure and prolonged QRS. BACKGROUND Simultaneous CRT improves hemodynamic and clinical performance in patients with moderate-to-severe heart failure (HF) and a wide QRS. Recent evidence suggests that sequentially(More)
While mild swallowing difficulties are commonly reported transiently following anterior cervical surgery, marked dysphagia is unusual. The authors report a patient who experienced severe and prolonged dysphagia following elective cervical corpectomies with iliac grafting and anterior plate fusion for multilevel cervical canal stenosis. The literature is(More)
An oral enteric-coated Vibrio anguillarum vaccine was developed by initially coating lyophilized bacteria onto 0.9 mm diameter dextrose sugar beads followed by an Eudragit L-30D coat to serve as enteric protection. Vaccine efficacy was determined by both an in vivo challenge with live pathogen and measurements of serum and mucus antibody levels by ELISA.(More)
Medulloblastoma (MB) is the most common type of brain tumor affecting children. These tumors are a significant cause of childhood mortality and morbidity, and more effective and less invasive treatment options are urgently required. To achieve these aims, it will be critical to develop a more comprehensive understanding of the molecular pathogenesis of MB.(More)
This case report describes the treatment of a 12-year-old Chinese boy with a Class II skeletal profile, an extreme overjet, and a retrusive mandible. The patient was teased at school because of his appearance, and he was experiencing negative psychosocial impacts, including shyness and falling grades. Orthodontic treatment had a positive psychosocial impact(More)
The therapeutic efficacy of 5-fluorouracil (5-FUra; 0.6 mg/day • 5 days) + leucovorin (LV; 1.8 rag/day • 5 days) and of 13q-labeled MN-14 anti-carcinoembryonic antigen IgG (275 /tCi single dose) was evaluated in size-matched (0.. These lines express varying amounts of carcinoembryonic antigen and exhibit varying degrees of in vitro responsiveness to 5-FUra.(More)
A combination of recombinant human interleukin 2 (rhl I.-2) and mouse monoclonal antibody R24 (recognizing the ganglioside <.,,,) was evaluated in patients with metastatic melanoma in a phase I trial, rhl I-2 was given at a constant daily dose of 1 x 10'units/m2i.v. over 6 h on days 1-5 and 8-12. R24 was given on days 8-12 at four dose levels (1, 3, 8, and(More)
1. Purpose The purpose of this policy is to establish criteria for the medical necessity of acupuncture with and without the application of electrical stimulation. 2. Definition Acupuncture refers to a technique or approach to patient care that involves the insertion of fine, hair-thin metallic (filiform) needles through the skin at specific points on the(More)
for helpful comments, discussions, and suggestions. Chang acknowledges financial support from Academic Research Fund Tier 1 provided by Ministry of Education (Singapore) under grant numbers SUG FY08, M58010006. ABSTRACT We outline a simple model in which optimizing firms choose corporate investment, external financing, and cash holding decisions(More)