George Thomson

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AMP-activated protein kinase (AMPK) acts as a cellular fuel gauge that responds to energy stress by suppressing cell growth and biosynthetic processes, thus ensuring that energy-consuming processes proceed only if there are sufficient metabolic resources. Malfunction of the AMPK pathway may allow cancer cells to undergo uncontrolled proliferation(More)
The colonic epithelium provides an interface between the host and micro-organisms colonising the gastrointestinal tract. Molecular recognition of bacteria is facilitated through Toll-like receptors (TLR). The colonic epithelium expresses relatively high levels of mRNA for TLR3 and less for TLR2 and -4. Little is known of the expression patterns and mode of(More)
A most critical reaction in the complement system for the elaboration of its biologic effects is the cleavage of the third component, C3, whose major fragment, C3b, can covalently bind (1) to target particles and soluble complexes. The bound C3b, or its degradation products, C3bi and C3d, can then mediate attachment of the target material to erythrocytes(More)
C3b receptors on human polymorphonuclear leukocytes (PMN) were nonrandomly distributed in small clusters on the plasma membranes of these cells when assessed by indirect immunofluorescence at 0 degree C using monospecific rabbit Fab' or F(ab')2 anti-C3b receptor and tetramethylrhodamine isothiocyanate (TRITC)-conjugated goat IgG anti-F(ab')2. When PMN were(More)
The efficacy of MDI-301, a non-toxic novel synthetic retinoid, was found to be equivalent to the natural 9-cis-retinoic acid (RA) in vitro against estrogen-dependent MCF7 and T47D breast cancer cell lines which express RA receptor (RAR) alpha. Both retinoids also showed similar efficacy against established PC-3 prostate carcinoma xenografts. MCF7 tumor(More)
AIM To investigate (i) the extent, nature and effectiveness of smokefree outdoor area (SFOA) policies in New Zealand, (ii) incentives and motivations for, and barriers to creating these SFOA. METHODS Literature and media searches were conducted for relevant material to February 2009. Nine in-depth interviews were conducted in October 2008, with key(More)
OBJECTIVE To examine the influences on contemporary smokefree area policy development in New Zealand. METHOD Semi-structured interviews were conducted with 62 New Zealand politicians and senior officials. They were asked about their views of possible interventions to reduce smoking around children, and how to achieve progress on smokefree homes, cars and(More)
AIM To explore how a smokefree parks policy was conceived, accepted and developed by and for Kapiti Coast District Council (KCDC). METHOD Thirteen people involved in the smokefree parks policy process for KCDC were interviewed in person during November-December 2008. Supporting documentation and websites were accessed and reviewed. RESULTS In September(More)