George Thomopoulos

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Although colistin methanesulfonate (CMS) has been used extensively in critically ill patients infected with multidrug-resistant organisms, the optimum dosing regimen remains to be determined. Herein, we examined the pharmacokinetics of three different dosing regimens of CMS, 3 million units every 8 h (regimen A), 4.5 million units every 12 h (regimen B), 9(More)
Objectives. To define the role of procalcitonin in the differential diagnosis, prognosis and follow-up of critically ill patients. Design: Prospective study during the 2-year period from January 1998–2000. Patients: One hundred nineteen critically ill patients: 29 with systemic inflammatory response syndrome (SIRS) without any signs of infection, 11 with(More)
INTRODUCTION The aim of this study was to assess the efficacy of two dosing schedules of recombinant human erythropoietin (rHuEPO) in increasing haematocrit (Hct) and haemoglobin (Hb) and reducing exposure to allogeneic red blood cell (RBC) transfusion in critically ill patients. METHOD This was a prospective, randomized, multicentre trial. A total of 13(More)
In order to investigate the effect of carbapenems on systemic endotoxemia, 20 patients with severe sepsis due to ventilator-associated pneumonia and Gram-negative bacteremia were enrolled; 10 (group A) were administered 1 g t.i.d. of imipenem/cilastatin and 10 (group B) 2 g t.i.d. of meropenem. Blood was sampled at 0 time and after 1, 2, 4, 6, 12, 24, 36,(More)
Cystic fibrosis (CF) is characterized by abnormal secretion from epithelial cells. We wanted to detect changes in the ultrastructural characteristics of cells within a number of exocrine tissues, including the colon, submandibular and parotid salivary glands of ΔF-508 CFTR animals. Therefore, in the present study a ΔF-508 CFTR mouse model was compared to(More)
The case of a previously healthy 47-year-old woman who was admitted to our hospital with symptoms of acute abdomen, septic shock and cutaneus rash is presented. The U.S. revealed cholelithiasis, cholecystitis and pericholecystitis and the patient was immediately treated by surgical removal of the gall bladder. In the blood culture a penicillin-susceptible(More)