George Sai-wah Tsao
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Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients.
- M. Fiala, Justin Lin, +11 authors G. Bernard
- Biology, Medicine
- Journal of Alzheimer's disease : JAD
The defective clearance of amyloid-beta (Abeta) in the brain of Alzheimer's disease (AD) patients is unexplained. The immunohistochemical studies of the frontal lobe and hippocampus show perivascular… Expand
Chromodomain helicase/adenosine triphosphatase DNA binding protein 1–like (CHD1l) gene suppresses the nucleus‐to‐mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival
Amplification of 1q21 has been detected in 58% to 78% of primary hepatocellular carcinoma cases, suggesting that one or more oncogenes within the amplicon play a critical role in the development of… Expand
Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development
Emerging evidence implicates the chromodomain helicase/ATPase DNA binding protein 1–like gene (CHD1L) as a specific oncogene in human hepatocellular carcinoma (HCC). To better understand the… Expand
Targeted activation of human Vγ9Vδ2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease.
Epstein-Barr virus-induced lymphoproliferative disease (EBV-LPD) after transplantation remains a serious and life-threatening complication. Herein we showed that the aminobisphosphonate… Expand
Activation of lytic cycle of Epstein‐Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma
- K. F. Hui, Dona N. Ho, C. M. Tsang, Jaap M Middeldorp, G. Tsao, A. K. Chiang
- Medicine, Biology
- International journal of cancer
- 15 October 2012
Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein‐Barr virus (EBV). We reported that suberoylanilide hydroxamic acid (SAHA) induced EBV lytic cycle in EBV‐positive gastric carcinoma… Expand
Co‐overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma
Lung cancer is a prevalent cancer with a poor prognosis. To develop a useful in vitro cell model, a cell line of lung squamous cell carcinoma (SCC‐35) was established.
Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA–microRNA regulatory network in nasopharyngeal carcinoma model systems☆
Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in Southeast Asia among the Chinese population. Aberrant regulation of transcripts has been implicated in many types of cancers including NPC.… Expand
Expression of Telomerase Reverse Transcriptase in Adult Goldfish Retina
Telomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear… Expand
EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells.
- L. Jiang, Yin-Lai Lui, +7 authors Ka-Leung Wong
- Chemistry, Medicine
- Chemical communications
- 22 May 2014
An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and… Expand
[Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Linzhou Henan].
- Yan-ru Qin, L. Wang, +5 authors G. Tsao
- Medicine, Biology
- Zhonghua yi xue yi chuan xue za zhi = Zhonghua…
- 1 December 2004
OBJECTIVE To characterize the profiles of chromosome imbalance in esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) from the high incidence area in Henan. METHODS… Expand