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  • Graham G Dark, Sally A. Hill, Vivien E. Prise, Gillian M. Tozer, George R. Pettit, David J. Chaplin
  • Medicine
  • Cancer research
  • 1997 (First Publication: 15 May 1997)
  • Selective induction of vascular damage within tumors represents an emerging approach to cancer treatment. Histological studies have shown that several tubulin-binding agents can induce vascularContinue Reading
  • George R. Pettit, Suresh B. Singh, Margaret L. Niven, Ernest Hamel, Jean Miller Schmidt
  • Chemistry, Medicine
  • Journal of natural products
  • 1987
  • The principal antineoplastic constituent of the South African tree Combretum caffrum has been isolated and designated combretastatin A-1. The structure of this new cis-stilbene was unequivocallyContinue Reading
  • Patricia S. Lorenzo, Marzieh Beheshti, George R. Pettit, James C. Stone, Peter M. Blumberg
  • Chemistry, Medicine
  • Molecular pharmacology
  • 2000 (First Publication: 1 May 2000)
  • RasGRP is a recently described guanine nucleotide exchange factor (GEF) that possesses a single C1 domain homologous to that of protein kinase C (PKC). The phorbol ester [(3)H]phorbol 12,Continue Reading