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Nanomedicine‐based intraperitoneal therapy for the treatment of peritoneal carcinomatosis — Mission possible?☆
The current clinical management of PC is discussed, as well as recent advances in nanomedicine‐based IP delivery, which address important challenges to be overcome towards designing optimal nanocarriers for IP therapy in vivo. Expand
Prostate cancer vs. post‐biopsy hemorrhage: Diagnosis with T2‐ and diffusion‐weighted imaging
To assess the value of quantitative T2 signal intensity (SI) and apparent diffusion coefficient (ADC) to differentiate prostate cancer from post‐biopsy hemorrhage, using prostatectomy as theExpand
Design of smart GE11-PLGA/PEG-PLGA blend nanoparticulate platforms for parenteral administration of hydrophilic macromolecular drugs: synthesis, preparation and in vitro/ex vivo characterization.
EGFR-targeted polylactide-co-glycolide (PLGA) nanoparticles made by a blend of two different PLGA-based polymers can be considered highly promising as smart nanoparticulate platforms for the treatment of diseases characterized by EGFR overexpression by parenteral administration. Expand
Colloidal stability of nano-sized particles in the peritoneal fluid: towards optimizing drug delivery systems for intraperitoneal therapy.
The authors' data demonstrate strong aggregation of cationic and anionic nanoparticles in the peritoneal fluids, while only slight aggregation was observed for the PEGylated ones, and reflect on how to tailor improved delivery systems for IP therapy. Expand
Delivery of proteins to the brain by bolaamphiphilic nano-sized vesicles.
Results show that cationic bolaamphiphilic vesicles with ACh head groups are capable of delivering proteins across biological barriers, such as the cell membrane and the blood-brain barrier (BBB). Expand
Robot-assisted urologic surgery: safety and feasibility in the pediatric population.
Robot-assisted surgery appears to be safe and feasible for a variety of pediatric urologic procedures and will serve as a foundation for future and more complex minimally invasive pediatric urology operations. Expand
Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA.
This study demonstrates the feasibility of entrapping pegylated lipoplexes into a solid matrix system for a prolonged delivery of siRNA into the vagina. Expand
Controversies in Transrectal Ultrasonography and Prostate Biopsy
Some of the current controversies in sonographic guided biopsy of the prostate remain unsettled and there are also unanswered questions regarding repeat biopsy and protocols for managing patients with a diagnosis of high-grade intraepithelial neoplasia. Expand
Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori
It is found that LNA/2'OMe is capable of diffusing rapidly through native, undiluted, gastric mucus isolated from porcine stomachs, without degradation, and the ability of H. pylori hybridization was hampered by the presence of mucus. Expand