George R. Spratto

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Fed and 18-h fasted rats were given acute doses of either saline or the acetylcholinesterase inhibitor pinacolyl methylphosphonofluoridate (soman) 40, 60, or 80 micrograms/kg. After 30 min plasma samples were collected and assayed for glucose, insulin, glucagon, corticosterone, epinephrine and norepinephrine and the hypothalamus was isolated and assayed for(More)
The effects of cocaine, procaine, and lidocaine on open field and spontaneous (actophotometer) locomotor activities were assessed and compared in rats (1) treated acutely with morphine (single injection), (2) made dependent on morphine (SC pellets), (3) implanted with morphine and withdrawn at the time of peak dependence, and (4) implanted SC with(More)
Morphine dependence (following s.c. implantation of 207 mg morphine in pellet form) increases hexobarbital sleeping time in both male and female rats; this is accompanied by an apparent increase in brain sensitivity to hexobarbital. Only male morphine-dependent rats manifested a decrease in in vitro hepatic metabolism of hexobarbital as well as a(More)
The role of adrenal catecholamines in the control of gluconeogenesis was determined in adrenal-demedullated (AD) and sham-operated (SO) rats. In animals which were fasted, plasma levels of glucose, lactic acid, glycerol, alanine as well as liver or skeletal muscle glycogen, and incorporation of lactic acid-14C into glucose were not significantly different(More)
The effects of acute doses of soman (40, 60, or 80 micrograms/kg sc) in rats were evaluated for toxic symptoms as well as for changes in plasma levels of glucose, insulin, glucagon, corticosterone, norepinephrine, and epinephrine. The relationship between changes in these levels and depressed acetylcholinesterase activity in the hypothalamus was determined.(More)
The effects of repeated administration of soman on plasma glucose levels, acetylcholinesterase (AChE) activity in erythrocytes and hypothalamus, and plasma levels of corticosterone, glucagon, insulin, epinephrine, and norepinephrine were studied in male rats. Rats were given soman subcutaneously (sc), either 30 micrograms/kg every 24 hr for 5 or 12 days or(More)
The importance of age as an experimental variable in the evaluation of the analgesic, thermic, and respiratory depressant effects to morphine was studied in male rats one and one-half, six, and ten months of age. Significant age-related responses were observed in both the analgesic and thermic responses to morphine. Also, following a dose of 30 mg/kg(More)