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Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors.

• Kenneth S. Bell, Mohammed Sebaihia, +29 authors Ian K. Toth
• Proceedings of the National Academy of Sciences…
• 2004

The bacterial family Enterobacteriaceae is notable for its well studied human pathogens, including Salmonella, Yersinia, Shigella, and Escherichia spp. However, it also contains several plant… (More)

The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.

• Peter C. Fineran, Tim R Blower, Ian J Foulds, David P. Humphreys, Kathryn S. Lilley, George P. C. Salmond
• Proceedings of the National Academy of Sciences…
• 2009

Various mechanisms exist that enable bacteria to resist bacteriophage infection. Resistance strategies include the abortive infection (Abi) systems, which promote cell death and limit phage… (More)

Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa.

• Michael K. Winson, Miguel Cámara, +7 authors Barrie W. Bycroft
• Proceedings of the National Academy of Sciences…
• 1995

Pseudomonas aeruginosa produces a spectrum of exoproducts many of which have been implicated in the pathogenesis of human infection. Expression of some of these factors requires cell-cell… (More)

Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control.

• Nicholas R Thomson, Michael M. Crow, Simon J. McGowan, Amanda Cox, George P. C. Salmond
• Molecular microbiology
• 2000

Serratia sp. ATCC 39006 produces the carbapenem antibiotic, carbapen-2-em-3-carboxylic acid and the red pigment, prodigiosin. We have previously reported the characterization of a gene, carR,… (More)

Biosynthesis of tripyrrole and beta-lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem…

• Peter C. Fineran, Holly Slater, Lee Everson, Katie Hughes, George P. C. Salmond
• Molecular microbiology
• 2005

Summary Serratia sp. ATCC 39006 (39006) uses a complex hierarchical regulatory network allowing multiple inputs to be assessed before genes involved in secondary metabolite biosynthesis are… (More)

The biosynthesis and regulation of bacterial prodiginines

• Neil R. Williamson, Peter C. Fineran, Finian J Leeper, George P. C. Salmond
• Nature Reviews Microbiology
• 2006

The red-pigmented prodiginines are bioactive secondary metabolites produced by both Gram-negative and Gram-positive bacteria. Recently, these tripyrrole molecules have received renewed attention… (More)

Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and…

• Neil R. Williamson, Henrik Toft Simonsen, +5 authors George P. C. Salmond
• Molecular microbiology
• 2005

The biosynthetic pathway of the red-pigmented antibiotic, prodigiosin, produced by Serratia sp. is known to involve separate pathways for the production of the monopyrrole, 2-methyl-3-n-amyl-pyrrole… (More)

Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.

• Mathew T. G. Holden, S Ram Chhabra, +14 authors Paul D. Williams
• Molecular microbiology
• 1999

In cell-free Pseudomonas aeruginosa culture supernatants, we identified two compounds capable of activating an N-acylhomoserine lactone (AHL) biosensor. Mass spectrometry and NMR spectroscopy… (More)

Membrane traffic wardens and protein secretion in gram-negative bacteria.

• George P. C. Salmond, Phillip J Reeves
• Trends in biochemical sciences
• 1993

Recent progress in the genetic analysis of protein secretion in diverse Gram-negative bacteria has revealed three major, highly conserved but functionally independent pathways that involve accessory… (More)

Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways.

• Holly Slater, Matthew J Crow, Lee Everson, George P. C. Salmond
• Molecular microbiology
• 2003

Serratia sp. ATCC 39006 produces two secondary metabolite antibiotics, 1-carbapen-2-em-3-carboxylic acid (Car) and the red pigment, prodigiosin (Pig). We have previously reported that production of… (More)

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