George P. Moore

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The statistical analysis of two simultaneously observed trains of neuronal spikes is described, using as a conceptual framework the theory of stochastic point processes.The first statistical question that arises is whether the observed trains are independent; statistical techniques for testing independence are developed around the notion that, under the(More)
In a growing class of neurophysiological experiments, the train of impulses ("spikes") produced by a nerve cell is subjected to statistical treatment involving the time intervals between spikes. The statistical techniques available for the analysis of single spike trains are described and related to the underlying mathematical theory, that of stochastic(More)
The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of(More)
The consequences of inhibitory or excitatory synaptic input between pacemaker neurons were predicted mathematically and through digital-computer simulations, and the predicted behavior was found to occur in abdominal ganglia of Aplysia and in stretch receptors of Procambarus. Discharge patterns under conditions that do not involve interneuronal feedback are(More)
This study introduces a new method for studying, quantitatively, the dynamics of finger movement using data obtained from sequences of key strikes on a computer-interfaced piano keyboard. We have called this quantitative digitography (QDG). This initial article introduces the method in a group of patients with Parkinson's disease and in a group of healthy(More)
Temporal information processing was studied in humans attempting to tap a key in synchrony with a metronome whose base period was subjected to subliminal random changes. Statistical measures of the sequential timing of metronome and key-tap events were compared with similar time series generated by computer-simulated models of synchronization strategies.(More)
The electroglottogram (EGG) is known to be related to vocal fold motion. A major hypothesis undergoing examination in several research centers is that the EGG is related to the area of contact of the vocal folds. This hypothesis is difficult to substantiate with direct measurements using human subjects. However, other supporting evidence can be offered. For(More)