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BACKGROUND The UHRF1 gene possesses an essential role in DNA methylation maintenance, but its contribution to tumor suppressor gene hypermethylation in primary human cancers currently remains unclear. METHODS mRNA expression levels of UHRF1, DNMT1, DNMT3A, DNMT3B, and E2F1 were evaluated in 105 primary nonsmall cell lung carcinomas by quantitative(More)
BACKGROUND Personalized drug prescription can be benefited from the use of intelligent information management and sharing. International standard classifications and terminologies have been developed in order to provide unique and unambiguous information representation. Such standards can be used as the basis of automated decision support systems for(More)
UNLABELLED BACKGROUND Identification of drug-drug and drug-diseases interactions can pose a difficult problem to cope with, as the increasingly large number of available drugs coupled with the ongoing research activities in the pharmaceutical domain, make the task of discovering relevant information difficult. Although international standards, such as(More)
Teleconsultation services for cardiology patients have been installed and are in routine use since December 2000, connecting a primary health center in rural Crete to a regional hospital. Since efficiency and effectiveness are key factors in the acceptance of the service, integration of the services with the primary health record, support of clinical(More)
Local recurrence in oral squamous cell carcinoma (OSCC) despite clear surgical margins may indicate the presence of residual, sub-microscopic disease. Molecular assessment of surgical margins may provide a greater prognostic sensitivity compared to histopathology. We aimed to determine whether promoter methylation in deep and mucosal resection margins can(More)
General mortality rates and specific mortality rates by major causes of death (coronary disease, cancer, tuberculosis, traffic accidents, suicide, vascular disorders of central neural system) in Greece have been studied throughout the 30-year period 1967–1996 and time trends have being calculated by nonlinear models of trend analysis. The results confirm(More)
In this study preliminary results are presented by the Hellenic part (n=10,451, children's response rate: 71.87%) of the BECAN study. This study, funded by EU's FP7 (ID: 223478), was an international epidemiological field research in a representative randomly selected sample of school children ageing 11, 13 and 16 years old in 9 Balkan countries, conducted(More)
BACKGROUND Child abuse is a health and social problem, and few screening instruments are available for the detection of risk in primary health care. The aim was to develop a screening instrument to be used by professionals in the public health care sector, thus enabling the detection of infants and toddlers at risk of emotional and physical abuse and(More)
The paper presents Panacea, a semantic-enabled framework capable of offering drug-drug and drug-diseases interaction discovery. For enabling this kind of service, medical information and terminology had to be translated to ontological terms and be appropriately coupled with medical knowledge of the field. International standards for diseases and dug(More)