George N Rolinson

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Sir: A number of important pathogens which are resistant to penicillins and cephalosporins owe their resistance to the production of a fi-lactamase. If this fl-lactamase could be inhibited adequately in vivo it would be expected that infections caused by such organisms could be successfully treated with the penicillins and cephalosporins now already(More)
Flucloxacillin, a new isoxazole penicillin, is active against penicillinase-producing strains of Staphylococcus aureus and is well absorbed in man after oral and intramuscular administration. Compared with isoxazole penicillins in current clinical use-namely, oxacillin, cloxacillin, and dicloxacillin-flucloxacillin has proved as active against Gram-positive(More)
This year (2007) marks the 50th anniversary of [corrected] discovery of 6-aminopenicillanic acid (6-APA), the precursor of all semi-synthetic penicillins [corrected] This review, by a scientist who played a major part in the discovery and a physician who participated in the early clinical trials of these antibiotics, tells the story of the discovery and of(More)
The effect of penicillins and cephalosporins on the rate of growth of individual cells of Escherichia coli on agar was determined by measurement of cell length using photomicrographs taken at frequent intervals. When exposed to cephalexin or carbenicillin at twice the minimum inhibitory concentration cell division was inhibited but growth in length(More)
Sutherland, R. (Beecham Research Laboratories Ltd., Betchworth, Surrey, England), and G. N. Rolinson. Characteristics of methicillin-resistant staphylococci. J. Bacteriol. 87:887-899. 1964.-Cultures of naturally occurring methicillin-resistant staphylococci obtained from a number of hospitals were examined for the nature and degree of resistance to(More)