George Michael Strain

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Deafness in blue-eyed white cats: The uphill road to solving polygenic disorders The pure white cat with luminous blue eyes is an attractive image familiar to many. These animals are well-known to be commonly affected by a congenital hereditary deafness that may affect one or both ears; the deafness is linked to the so-called W gene. Reports of this(More)
Visual system responses (visual evoked potentials) to flash (FVEP) and pattern reversal (PRVEP) stimuli were recorded in mice. Two strains were used: black C57BL/6J mice and agouti B6CBAF1/J mice (first generation offspring of C57BL/6J females and CBA/J males.) Subjects were sedated with ketamine and xylazine. Flash rate (FVEP) and stimulus spatial(More)
Congenital deafness in dogs and cats is primarily of the hereditary sensorineural form associated with white pigmentation genes, although acquired forms of deafness are possible. Highest prevalence is seen in white cats, especially those with blue eyes, and the Dalmatian, with many other dog breeds affected to some extent. This deafness results from(More)
Recordings of averaged brain stem auditory-evoked potentials were obtained from 13 Beagle pups of both genders to document the postnatal development of the response from age 1 to 76 days. Responses were recorded between needle electrodes placed on the vertex and the ipsilateral ear, with ground at the interorbital line. Recordings were performed without(More)
A sample and hold amplifier system has been described which is capable of eliminating stimulus artifacts from a variety of biological recordings which would otherwise be impossible to interpret during electrical stimulation. Factors contributing to the prolongation of stimulus artifact are discussed in relation to the design requirements of this system. The(More)
Hereditary loss of hearing affects many breeds of the domestic dog, but the Dalmatian has the highest prevalence. Approximately 30% are affected in the United States (U.S.) population. It is widely accepted that a relationship exists between deafness and pigmentation in the dog and also in other animals. While the Dalmatian exemplifies this relationship,(More)
Electrodiagnostic visual testing (electroretinogram [ERG] and visual-evoked potential [VEP]) was performed on 5 ruminants (3 lambs, 1 kid, and 1 steer) with thiamine-responsive polioencephalomalacia (PEM) and on 2 sheep with listeriosis. The lambs and kid had typical clinical signs of PEM, especially blindness. In these animals, the ERG was normal but the(More)
Tubes containing specific monoclonal antibodies to the neural cell adhesion molecule (N-CAM) were applied to transected sciatic nerves to attempt to perturb the recovery of muscle function. Physiological recordings were used to estimate the return of function. The decline of implanted antibody over 28 days was estimated and negatively correlated with the(More)
To screen for congenital deafness, brainstem auditory-evoked potential (BAEP) testing was performed on 1031 Dalmatians from three geographically separated areas. Phenotypic marker assessment was done to determine markers possibly associated with deafness. Markers included sex, hair coat color, pigmentation of different areas of skin (eye rims, nose, and(More)