George Mahmourides

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The conversion of d-xylose to ethanol by the yeast Pachysolen tannophilus is relatively inefficient in batch culture. The inefficiency has been attributed in part to concurrent utilization of ethanol in the presence of appreciable concentrations of d-xylose and to the formation of xylitol and other by-products. To increase the concentration of ethanol(More)
The formation of ethanol, xylitol, ribitol, arabitol and acetic acid from D-xylose byPachysolen tannophilus correlated with the limitation of growth. The correlation was consistent with these products being secondary metabolites.
Ethanol accumulation in aerobic batch cultures of Pachysolen tannophilus growing on D-xylose is associated with a transition to a state of low oxygen consumption, and the events triggering the accumulation differ from those of a Crabtree effect. The transition explains the accumulation of ethanol at only a particular interval during the growth of the(More)
Induced mutants, selected for their defective growth on d-xylose while retaining the ability to grow normally on d-glucose, were studied in Pachysolen tannophilus, a yeast capable of converting d-xylose to ethanol. Fourteen of the mutations were found to occur at nine distinct loci, and data indicated that many more loci remain to be detected. Most of the(More)
Two mutants of Pachysolen tannophilus were isolated which produced considerably more acetic acid from several sugars than a wild type strain. Such mutants are of potential interest for the production of acetic acid rather than ethanol from lignocellulosic hydrolysates.
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