G M Whitesides37
J Christopher Love22
Scott T Phillips22
Kateri E Paul21
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It is difficult to mix solutions in microchannels. Under typical operating conditions, flows in these channels are laminar-the spontaneous fluctuations of velocity that tend to homogenize fluids in turbulent flows are absent, and molecular diffusion across the channels is slow. We present a passive method for mixing streams of steady pressure-driven flows(More)
This manuscript describes a unique class of locomotive robot: A soft robot, composed exclusively of soft materials (elastomeric polymers), which is inspired by animals (e.g., squid, starfish, worms) that do not have hard internal skeletons. Soft lithography was used to fabricate a pneumatically actuated robot capable of sophisticated locomotion (e.g., fluid(More)
This review describes microfluidic systems in poly(dimethylsiloxane) (PDMS) for biological studies. Properties of PDMS that make it a suitable platform for miniaturized biological studies, techniques for fabricating PDMS microstructures, and methods for controlling fluid flow in microchannels are discussed. Biological procedures that have been miniaturized(More)
  • Stephan K W Dertinger, Daniel T Chiu, Li Jeon, George M Whitesides, J C Mcdonald, E Ostuni +4 others
This paper describes the generation of gradients having complex shapes in solution using microfluidic networks. Flowing multiple streams of fluid each carrying different concentrations of substances laminarly and side-by-side generated step concentration gradients perpendicular to the direction of the flow. Appropriately designed networks of microchannels(More)
Long-chain alkanethiols, HS(CH2),,X, adsorb from solution onto gold surfaces and form ordered, oriented monolayer films. The properties of the interfaces between the films and liquids are largely independent of chain length when n > 10; in particular, wetting is not directly influenced by the proximity of the underlying gold substrate. The specific(More)
—Because of the low dimensional power of its force scaling law, surface tension is appropriate for carrying out reshaping and assembly in the microstructure size domain. This paper reviews work on surface tension powered self-assembly of microstructures. The existing theoretical approaches for rotational assembly are unified. The demonstrated fabrication(More)
This paper describes a technique for growing filamentous cells of Escherichia coli with defined shapes, including crescents, zigzags, sinusoids, and spirals. The procedure begins with the fabrication of embossed microchambers in agarose. Cells are trapped in the chambers by placing a flat, flexible "ceiling", either a slab of agarose or(More)
Soft lithography represents a non-photolithographic strategy based on self-assembly and replica molding for carrying out micro-and nanofabrication. It provides a convenient, effective, and low-cost method for the formation and manufacturing of micro-and nanostructures. In soft lithography, an elastomeric stamp with patterned relief structures on its surface(More)