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Flumazenil is a recently discovered pharmacologic antagonist of the CNS effects of benzodiazepines. It acts by binding CNS benzodiazepine receptors and competitively blocking benzodiazepine activation of inhibitory GABAergic synapses. Animal studies and some human studies appear to demonstrate that flumazenil has weak intrinsic agonist activity; on the(More)
Human ingestion of denture cleansers leading to gastric perforation has not previously been described. A 27-year-old male ingested three denture cleanser tablets in water over two days in an attempt to cause a false-negative result on a workplace urine drug screen. Seven days later he presented to an emergency department with a perforated gastric ulcer. A(More)
OBJECTIVE The nature of pediatric poisonings is dynamic, with changes occurring over time. We evaluated poisoning in children younger than 6 years for trends during an 11-year period regarding the substances involved in the poisoning, medical outcomes, and health care use. METHODS This was retrospective study of poisoning in children younger than 6 years(More)
Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects. A 40 year old male ingested venlafaxine without co-ingestants in a suicide attempt. The patient developed refractory ventricular fibrillation and expired approximately 9 hours post-ingestion. ECG monitoring revealed(More)
A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department. The patient developed tonic-clonic seizures, which resolved with diazepam and midazolam therapy. The patient then developed profound bradycardia that progressed to ventricular fibrillation and asystole. A postmortem toxicology analysis reported(More)
The purpose of this study was to prospectively compare the effectiveness of three different gut decontamination methods in 51 patients presenting to an emergency department with tricyclic antidepressant overdose. Patients were randomized to three treatments; Group 1 received activated charcoal, Group 2 received saline lavage followed by activated charcoal,(More)
UNLABELLED In 2001, a new antivenin was introduced to the United States and became widely available in the snakebite season of 2002. We investigated what impact this may have had on snakebite treatment and medical outcome. METHOD The study used a retrospective review of all snakebites to humans reported to the National Poison Center Database System from(More)
Review of toxicology screening results in our level 1 trauma center revealed that approximately 15% of urine drug screens were positive for cocaine metabolite. Our objective was to determine the prevalence of true acute cocaine intoxication and if measurement of serum would improve upon the accuracy of toxicology screening for identifying acute cases of(More)
The objective of this study was to describe a novel presentation of peripheral vasculitis associated with levamisole-adulterated cocaine. Cocaine abuse is widespread in the United States with 5.3 million people using cocaine in 2008. Over the past decade, drug enforcement officials have noticed the presence of levamisole in confiscated cocaine samples as an(More)
BACKGROUND The morbidity associated with snakebite envenomation has not been well documented. METHOD Using a standardized questionnaire all patients with snakebite reported to a regional poison center during the year 2001 were followed after hospital discharge by telephone until resolution of symptoms. RESULTS One hundred and twenty-eight snakebite(More)