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OBJECTIVE To evaluate the efficacy and safety of conversion to lacosamide 400 mg/day monotherapy in adults with focal epilepsy. METHODS This historical-controlled, double-blind study (NCT00520741) enrolled patients aged 16-70 years on stable doses of 1-2 antiepileptic drugs (AEDs) and experiencing 2-40 partial-onset seizures per 28 days during the 8-week(More)
miR-124-1 is a tumour suppressor microRNA (miR). Epigenetic deregulation of miRs is implicated in carcinogenesis. Promoter DNA methylation and histone modification of miR-124-1 was studied in 5 normal marrow controls, 4 lymphoma, 8 multiple myeloma (MM) cell lines, 230 diagnostic primary samples of acute myeloid leukaemia (AML), acute lymphoblastic(More)
Multimedia repositories, libraries, and databases ooer the potential for providing students with access to a wide variety of interconnected information resources. However, in order to realize this potential, multimedia systems should provide access to information and activities that support eeective knowledge construction and learning by students. This(More)
Background. To examine the results of treatment of Extramammary Paget's disease (EMPD) in ethnic Chinese. Method. Between 1990 and 2010, patients treated for EMPD were reviewed. Data were analyzed retrospectively. Results. Forty-eight patients were treated by surgical resection. Local recurrence rate was 14.6%. The postresection defects were repaired by(More)
BACKGROUND hRad9 is a cell cycle checkpoint gene that is up-regulated in breast cancer. We have previously shown that the mRNA up-regulation correlated with tumor size and local recurrence. Immunohistochemical studies were made to better define the role of hRad9 in breast carcinogenesis. METHODS Localisation of hRad9 protein were performed on paired tumor(More)
Homogeneity or heterogeneity of cells is the most fundamental and important features of analyzing biological associations of genes and gene products. Recent bioinformatics technology requires an automated high-throughput analysis application that can handle massively produced data from next generation sequences and dramatically increased size of public(More)
As a composite table, a stack table is made up of a varying number of child tables that are placed one on top of another without any gaps. Unlike a regular table that has a fixed number of columns throughout the rows, a typical stack table allows each of its child tables to have its own number of columns and headers and each can vary its size, layout and(More)
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