George L. Spaeth

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Glaucoma is a leading cause of blindness in virtually every country. Development of an accurate diagnostic test for presymptomatic detection of individuals at risk is an urgent requisition for this condition. Herein, we report mapping of a new adult-onset primary open-angle glaucoma (POAG) locus on 5q22.1 (GLC1G) and identification of its defective gene.(More)
Aniridia occurs as a phenotypically heterogeneous condition which may be inherited as an autosomal dominant disorder or as part of several systemic syndromes. It has been linked with the loci of chromosomes 1 and 2 and associated with the deletion of the p-13 band of chromosome 11. Aniridia may occur in a highly penetrant form in association with other(More)
OBJECTIVE To determine race-, age-, gender-, and refractive error-related differences in the size and topography of the optic disc in healthy Americans. DESIGN Population-based study. SETTING Eastern and southeastern health districts of Baltimore, Md. PARTICIPANTS A population-based sample of 4877 non-institutionalized black and white individuals aged(More)
We reviewed 75 consecutive cases of extracapsular cataract extraction and posterior chamber intraocular lens implantation combined with trabeculectomy in 69 patients with glaucoma. The mean preoperative intraocular pressure was 19.3 mm Hg on an average of 2.3 glaucoma medications. Visual acuity improved in 58 eyes (77%) at two months, with an average(More)
In 22 subjects with phakic open-angle glaucoma, trabeculectomies were performed at intervals of three hours to one year after argon laser treatment (ALT). In ten patients the ALT was done with informed consent anticipating that trabeculectomy would be performed at a scheduled time (three hours to two weeks following laser therapy). In 12 other patients,(More)
The pathogenesis of normal-tension glaucoma remains unknown. Because ocular vasospasm has been proposed as a possible mechanism, we investigated ocular vessel flow velocity in normal-tension glaucoma patients at rest and under treatment with a cerebral vasodilator. Ten normal-tension glaucoma patients and nine age- and gender-matched controls had flow(More)
To assess change over time in the optic disk and the associated change in visual field, we retrospectively reviewed perimetry results and optic disk photographs of adult patients treated for glaucoma. Three glaucoma specialists masked to the clinical course independently reviewed optic disk stereophotographs and visual fields taken before and after(More)
The authors studied 232 glaucoma patients in an attempt to shed light on the implications of the pit-like localized cupping of the optic nerve often referred to as an "acquired pit of the optic nerve" (APON) both in low-tension glaucoma and in glaucoma associated with elevated intraocular pressure (IOP). Twenty (74%) of the 27 patients with low-tension(More)
OBJECTIVE Quantitative data are not available regarding the morphological appearance of optic nerve morphology after arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION). The purpose of this study is to evaluate the appearance of the optic nerve head in patients after AAION and NAION with the(More)