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  • Roger G Pertwee, Allyn C. Howlett, +9 authors Ruth Alexandra Ross
  • Medicine, Biology
  • Pharmacological Reviews
  • 2010 (First Publication: 1 December 2010)
  • There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9-tetrahydrocannabinol, numerousExpand
  • Douglas Osei-Hyiaman, Michael A Depetrillo, +8 authors George Kunos
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2005 (First Publication: 2 May 2005)
  • Endogenous cannabinoids acting at CB(1) receptors stimulate appetite, and CB(1) antagonists show promise in the treatment of obesity. CB(1) (-/-) mice are resistant to diet-induced obesity evenExpand
  • Zoltán Járai, Jens Andreas Wagner, +10 authors George Kunos
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1999 (First Publication: 23 November 1999)
  • Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide), elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, CB1 and CB2, have beenExpand
  • Károly Varga, Jens Andreas Wagner, Devin T. Bridgen, George Kunos
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1998 (First Publication: 1 August 1998)
  • Macrophages are the primary cellular targets of bacterial lipopolysaccharide (LPS), but the role of macrophage-derived cytokines in LPS-induced septic shock is uncertain. Recent evidence indicatesExpand