• Publications
  • Influence

Claim Your Author Page
Ensure your research is discoverable on Semantic Scholar. Claiming your author page allows you to personalize the information displayed and manage your publications. Semantic Scholar automatically creates author pages based on data aggregated from public sources and our publisher partners.
  • Steven Y. Park, Rosemarie Kelly, +15 authors David S Perlin
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 2005 (First Publication: 1 August 2005)
  • ABSTRACT An association between reduced susceptibility to echinocandins and changes in the 1,3-β-d-glucan synthase (GS) subunit Fks1p was investigated. Specific mutations in fks1 genes fromExpand
  • Joel C Bowman, George K. Abruzzo, +6 authors Cameron M. Douglas
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2001 (First Publication: 1 December 2001)
  • ABSTRACT Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. CaspofunginExpand
  • George K. Abruzzo, Amy M. Flattery, +9 authors Kenneth Bartizal
  • Medicine, Biology
  • Antimicrobial agents and chemotherapy
  • 1997 (First Publication: 1 November 1997)
  • The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. TheExpand
  • Cameron M. Douglas, J A D'Ippolito, +9 authors Myra Berman Kurtz
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 1997 (First Publication: 1 November 1997)
  • Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified aExpand
  • Nancy Hall Colburn, E J Wendel, George K. Abruzzo
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1981 (First Publication: 1 November 1981)
  • The JB-6 mouse epidermal cell line has been used as a model system for studying the mechanism of late-stage promoter-dependent preneoplastic progression. The studies reported here are concerned withExpand