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Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS
Eukaryotic DNA replication is initiated at multiple origins of replication, where many replication proteins assemble under the control of the cell cycle [1]. A key process of replication initiationExpand
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Comparative Analysis of Satellite DNA in the Drosophila melanogaster Species Complex
Satellite DNAs are highly repetitive sequences that account for the majority of constitutive heterochromatin in many eukaryotic genomes. It is widely recognized that sequences and locations ofExpand
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Mechanisms of rDNA Copy Number Maintenance.
rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNAExpand
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Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells
rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies agingExpand
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Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells
Although non-random sister chromatid segregation has been proposed to underlie asymmetric cell divisions, the underlying biological significance or mechanisms remained elusive. Here we show thatExpand