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87. Horton JA, Marano GD, Kerber CW, et al. Polyvinyl alcohol foam-Gelfoam for therapeutic embolization: a synergistic mixture. AJNR Am J Neuroradiol. 1983;4:143–147. 88. Fournier D, TerBrugge KG, Willinsky R, et al. Endovascular treatment of intracerebral arteriovenous malformations: experience in 49 cases. J Neurosurg. 1991;75:228–233. 89. Schweitzer JS,(More)
A number of techniques have been developed during the past four decades to evaluate cerebral perfusion. The oldest used 133 Xe, a lipophilic radioactive tracer that easily diffuses through the blood-brain barrier (BBB). It was either injected or inhaled, and probes placed over the scalp were used to measure perfusion to the cerebral cortex. 1,2 In the(More)
Despite widespread applications in biomedical research, the role of models and modeling is often controversial and ill understood. It is usual to find that fundamental definitions, axioms, and postulates used in the modeling process have become tacit assumptions. What is essential, however, is a clear vision of the fundamental principles of modeling. This(More)
I n 1994, a panel appointed by the Stroke Council of the American Heart Association authored guidelines for the management of patients with acute ischemic stroke. 1 After the approval of the use of intravenous recombinant tissue plas-minogen activator (rtPA) for treatment of acute ischemic stroke by the Food and Drug Administration, the guidelines were(More)
PURPOSE An alternative endovascular treatment to conventional transarterial embolization of cerebral arteriovenous malformations (AVMs) is proposed. CONCEPT According to this proposed treatment, selected AVMs could undergo transvenous retrograde nidus sclerotherapy under controlled hypotensive anesthesia (TRENSH). RATIONALE It is hypothesized that(More)
The size of intracranial aneurysms is the only characteristic shown to correlate with their rupture. However, the critical size for rupture has varied considerably among previous accounts and remains a point of controversy. Our goal was to identify statistically significant clinical and morphological factors predictive of the occurrence of rupture and(More)
I ntracranial aneurysms are common, with a prevalence of 0.5% to 6% in adults, according to angiography and autopsy studies. 1 Most intracranial aneurysms are asymptom-atic and are never detected. Some are discovered incidentally in neuroimaging studies and some produce symptoms due to compression of neighboring nerves or adjacent brain tissue. Others are(More)
BACKGROUND AND PURPOSE Increased resistance in the venous drainage of intracranial arteriovenous malformations (AVMs) may contribute to their increased risk of hemorrhage. Venous drainage impairment may result from naturally occurring stenoses/occlusions, or if draining veins (DVs) undergo occlusion before feeding arteries during surgical removal, or after(More)
BACKGROUND AND PURPOSE Nidus rupture is a serious complication of intracranial arteriovenous malformation (AVM) embolotherapy, but its pathogenetic mechanisms are not well described. An AVM model based on electrical network analysis was used to investigate theoretically the potential role of hemodynamic perturbations for elevating the risk of nidus vessel(More)