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Many semiconductor quantum devices utilize a novel tunneling transport mechanism that allows picosecond device switching speeds. The negative differential resistance characteristic of these devices, achieved due to resonant tunneling, is also ideally suited for the design of highly compact, self-latching logic circuits. As a result, quantum device(More)
BACKGROUND Coronary artery disease leading to myocardial ischemia is the most common cause of heart failure. Apelin (APLN), the endogenous peptide ligand of the APJ receptor, has emerged as a novel regulator of the cardiovascular system. METHODS AND RESULTS Here we show a critical role of APLN in myocardial infarction (MI) and ischemia-reperfusion (IR)(More)
The resonant tunneling diode (RTD) has been widely studied because of its importance in the field of nanoelectronic science and technology and its potential applications in very high speed/functionality devices and circuits. Even though much progress has been made in this regard, additional work is needed to realize the full potential of RTD's. As research(More)
First augmented circuit simulator version was named NDR SPICE (1994) and was added with simple mechanisms like forced convergence routine to recover from oscillatory (non-convergence) situations in DC simulation. The second version, named QSPICE (1999), was augmented with homotopy-based convergence routine, named RTD-stepping as well as a novel limiting(More)
OBJECTIVE The function of the endothelial cell (EC)-enriched Rho family guanine nucleotide exchange factor, facio-genital dysplasia-5 (FGD5), is poorly understood. We sought to determine whether FGD5 regulates endothelial cytoskeletal reorganization and angiogenesis. METHODS AND RESULTS We observed that FGD5 is expressed in primary human EC isolated from(More)
Devices from three major groups of two-terminal devices, i.e., transit-time diodes, transferred-electron devices, and quantum-well devices, have been employed successfully to generate RF power at frequencies above 200 GHz. At frequencies up to 300 GHz, Si IMPATT diodes yielded the highest RF power levels from any fundamental solid-state source, e.g., 50 mW(More)
Vascular endothelial growth factor (VEGF)-dependent signals are central to many endothelial cell (EC) functions, including survival and regulation of vascular tone. Akt and endothelial nitric oxide synthase (eNOS) activity are implicated to mediate these effects. Dysregulated signaling is characteristic of endothelial dysfunction that sensitizes the(More)
Thrombotic microangiopathy (TMA) commonly involves injury of kidney glomerular endothelial cells (ECs) and fibrin occlusion of the capillaries. The mechanisms underlying repair of the microvasculature and recovery of kidney function are poorly defined. In the developing vasculature, the phosphoinositide 3-kinase (PI3K) α isoform integrates many growth(More)
The microvascular endothelium of the kidney glomerulus is injured in Shiga-like toxigenic bacterial infection, genetic or acquired loss of complement regulatory protein function, and allo-immune responses of solid-organ or bone marrow transplantation. Existing models of diseases with glomerular endothelial cell (EC) injury, collectively grouped as(More)