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- Robert S. Stephenson, Mark R. Boyett, George Hart, Theodora Nikolaidou, Xue Cai, Antonio F. Corno +3 others
- PloS one
- 2012

The general anatomy of the cardiac conduction system (CCS) has been known for 100 years, but its complex and irregular three-dimensional (3D) geometry is not so well understood. This is largely because the conducting tissue is not distinct from the surrounding tissue by dissection. The best descriptions of its anatomy come from studies based on serial… (More)

- Alicia D’Souza, Annalisa Bucchi, Anne Berit Johnsen, Sunil Jit R.J. Logantha, Oliver Monfredi, Joseph Yanni +8 others
- Nature communications
- 2014

Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic… (More)

- Alzbeta Chorvatova, Richard Snowdon, George Hart, Munir Hussain
- Molecular and cellular biochemistry
- 2004

We investigated the effects of pressure overload hypertrophy on inward sodium (I Na) and calcium currents (I Ca) in single left ventricular myocytes to determine whether changes in these current systems could account for the observed prolongation of the action potential. Hypertrophy was induced by pressure overload caused by banding of the abdominal aorta.… (More)

- Antonio Francesco Corno, Xue Cai, Caroline B. Jones, Giuseppina Mondani, Mark R. Boyett, Jonathan Charles Jarvis +1 other
- Front. Pediatr.
- 2013

INTRODUCTION
Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure.
MATERIALS AND METHODS
New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure… (More)

- Robert S. Stephenson, Mark R. Boyett, George Hart, Theodora Nikolaidou, Xue Cai, Antonio F. Corno +3 others
- 2012

We consider the problem of embroidering a design pattern , given by a graph G, using a single minimum length thread. We give an exact polynomial-time algorithm for the case that G is connected. If G has multiple connected components, then we show that the problem is NP-hard and give a polynomial-time 2-approximation algorithm. We also present results for… (More)

- Reza Ashrafi, Marianne Yon, Lucy Pickavance, Joseph Yanni Gerges, Gershan Davis, John Wilding +4 others
- 2016

- Jue Li, Sunil Jit Logantha, Joseph Yanni, Xue Cai, Halina Dobrzynski, George Hart +1 other
- EMBC
- 2015

This study used one-dimensional computer simulation to investigate the influence of heart failure on action potential conduction through the left Purkinje fibres to the left ventricle. The study was based on a rabbit model of left ventricular heart failure caused by volume and pressure overload. To simulate the effect of heart failure, we began with models… (More)

We show how to compute the smallest rectangle that can enclose any polygon, from a given set of polygons, in nearly linear time; we also present a PTAS for the problem, as well as a linear-time algorithm for the case when the polygons are rectangles themselves. We prove that finding a smallest convex polygon that encloses any of the given polygons is… (More)

We show how to compute the smallest rectangle that can enclose any polygon, from a given set of polygons, in nearly linear time; we also present a PTAS for the problem, as well as a linear-time algorithm for the case when the polygons are rectangles themselves. We prove that finding a smallest convex polygon that encloses any of the given polygons is… (More)

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