George D. Kritikos

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The cell envelope of Gram-negative bacteria is a formidable barrier that is difficult for antimicrobial drugs to penetrate. Thus, the list of treatments effective against these organisms is small and with the rise of new resistance mechanisms is shrinking rapidly. New therapies to treat Gram-negative bacterial infections are therefore sorely needed. This(More)
BACKGROUND Recent technological advances applied to biology such as yeast-two-hybrid, phage display and mass spectrometry have enabled us to create a detailed map of protein interaction networks. These interaction networks represent a rich, yet noisy, source of data that could be used to extract meaningful information, such as protein complexes. Several(More)
Fighting antibiotic resistance requires a deeper understanding of the genetic factors that determine the antibiotic susceptibility of bacteria. Here we describe a chemical-genomic screen in Escherichia coli K-12 that was designed to discover new aspects of antibiotic resistance by focusing on a set of 26 antibiotics and other stresses with poorly(More)
—In this paper we consider the problem of learning the genetic-interaction-map, i.e., the topology of a directed acyclic graph (DAG) of genetic interactions from noisy double knockout (DK) data. Based on a set of well established biological interaction models we detect and classify the interactions between genes. We propose a novel linear integer(More)
There are two basic categories of reflection, according to where the learner reflects on. In self-reflection, the learner reflects on her/his own actions, while in comparative reflection the learner reflects on others' actions. We propose an alternative reflection type, as a subcategory of the comparative reflection, the analogical reflection. In analogical(More)
The modern educational technological environments do not focus on the transmission of knowledge, but on the triggering of metacognitive functions. Reflection acts as a booster for metacognition. In this work, we present initially a review of the research on reflection in technological environments. Through the review and in combination with the benefits of(More)
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