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In order to clarify the significance of the various components of the movement-related cortical potentials, scalp-recorded potential changes associated with voluntary, self-paced middle finger flexion and extension were studied by an opisthochronic averaging program in 14 normal right-handed subjects. Topographical study, based on 14 simultaneously recorded(More)
In order to clarify the time relationship and functional significance of post-motion components of the movement-related cortical potential, averaged cortical potentials associated with voluntary and passive movements were compared mainly with respect to their scalp topography. Fourteen channels of scalp EEG, together with EOG and EMG, were simultaneously(More)
—The decentralized control problem for discrete-event systems addressed in this paper is that of several communicating supervisory controllers, each with different information, working in concert to exactly achieve a given legal sublanguage of the uncontrolled system's language model. A novel information structure model is presented for dealing with this(More)
Eighteen patients with acute optic neuritis underwent optic nerve magnetic resonance imaging (MRI) before and after injection of gadolinium-diethylene triamine pentacetic acid (Gd-DTPA). Ten were re-examined 4 weeks later. Leakage of Gd-DTPA across the blood-optic nerve barrier was a consistent finding in the acute lesion, and its presence was associated(More)
We have recorded movement-related cortical potentials (MRCPs) to voluntary middle finger extension from 10 young and 10 old subjects free of neurological disease using the method of detecting EMG onset associated with each movement described by Barrett et al. (1985). The slow potential shifts preceding movement were measured by fitting a linear regression(More)
Event-related potentials were measured in normal young subjects during a memory-scanning paradigm modified from one proposed by Sternberg. The stimuli used were verbal (digits) and non-verbal (musical notes) with the verbal stimuli and notes presented acoustically and the verbal stimuli also presented visually. In this paradigm each set of stimuli was(More)
Twenty-three patients with multiple sclerosis (MS) and 1 patient with isolated optic neuritis (mean age 37.5 yrs, average duration of disease 10 yrs) were tested with auditory and visual cognitive event-related potentials (ERPs) using an oddball paradigm. The results were compared with data from 19 age-matched healthy controls. All patients had magnetic(More)
Event-related potentials (ERP) and regional cerebral blood flow (rCBF) activation using 15O-labeled water associated with retrieval and retention of episodic memory were studied during a visual paired-association task with delayed response in eight healthy subjects. In both studies, the subjects memorized four pairs of figures during the learning period.(More)
In order to develop an experimental paradigm for clinical application of cognitive event-related potentials we have recorded these potentials in a group of 27 healthy Japanese, aged 20-78 years, using all 4 stimulus/response combinations of auditory or somatosensory stimuli requiring a counting or button-press response. In an oddball paradigm we recorded N1(More)
An auditory discrimination paradigm was employed to elicit event-related brain potentials in 13 patients with Alzheimer's disease and 14 patients with multi-infarct dementia. The P300 latency was significantly prolonged in 12 patients with dementia compared with age-matched controls and showed a significant negative correlation with the score of Wechsler(More)