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PURPOSE To describe the pharmacokinetics occurring after the direct injection of triamcinolone acetonide into the vitreous humor of humans. DESIGN Interventional case series. PARTICIPANTS Five patients who received a single 4-mg intravitreal injection of triamcinolone acetonide. METHODS An aqueous humor sample was obtained from 5 eyes via an anterior(More)
PURPOSE To describe the prevalence and incidence of loss of visual field among patients with birdshot chorioretinopathy (BSCR) and to describe the effect of therapy on such field loss in these patients. DESIGN Retrospective cohort study. METHOD SETTING Single-center, academic practice. STUDY POPULATION Fifty-five patients with BSCR evaluated from(More)
PURPOSE To describe the incidence of vision loss and of ocular complications attributable to birdshot retinochoroidopathy and to describe the association between therapy and the incidence thereof. DESIGN Retrospective cohort study. METHODS SETTING Single-center, academic practice. STUDY POPULATION Forty patients with birdshot retinochoroidopathy(More)
PURPOSE To compare the relative effectiveness and side effect profiles of antimetabolite drugs in the treatment of noninfectious ocular inflammation. DESIGN Retrospective cohort study. PARTICIPANTS A total of 257 patients with inflammatory eye disease seen in a single-center, academic practice and treated with an antimetabolite as a first-line(More)
PURPOSE To describe risk factors for the presence of cystoid macular edema (CME) among patients presenting with intermediate uveitis. DESIGN Cross-sectional study. METHODS SETTINGS Single-center, academic practice. STUDY POPULATION Two hundred and eight patients with intermediate uveitis evaluated from July 1, 1984 through September 30, 2006. (More)
OBJECTIVE To evaluate the clinical presentation, treatment, and long-term follow-up of eyelid Merkel cell carcinoma. DESIGN Retrospective noncomparative interventional case series. PARTICIPANTS Fourteen patients with primary eyelid Merkel cell carcinoma. METHODS Cases of Merkel cell carcinoma for which long-term follow-up was available were solicited(More)
PURPOSE To estimate the incidences of ocular complications and vision loss in patients with multifocal choroiditis with panuveitis (MFCPU) and to describe the association between therapy and the incidences thereof. DESIGN Retrospective cohort study. PARTICIPANTS Sixty-six patients (122 eyes) with MFCPU evaluated from January 1984 through June 2005 at a(More)
PURPOSE To determine the vitreous penetration of the new fourth-generation topical fluoroquinolones moxifloxacin 0.5% and gatifloxacin 0.3%. METHODS A prospective randomized clinical trial comprising 12 eyes of 12 patients scheduled for pars plana vitrectomy between August 2003 and September 2003 was performed in a clinical practice. The patients were(More)
OBJECTIVE To review the causes and prognosis of sixth nerve palsies in patients who are 20 to 50 years of age. DESIGN Retrospective, noncomparative case series. PARTICIPANTS All patients aged 20 to 50 years with a nontraumatic sixth nerve palsy seen in a neuro-ophthalmic practice from 1994 to 2000. INTERVENTION Diagnostic testing to determine the(More)
A small, mosaic, C-band negative marker chromosome was detected in amniocyte cultures during prenatal diagnosis due to advanced maternal age. Following spontaneous premature labor at 29 weeks gestation, a dysmorphic infant was delivered, with flat nasal bridge, short palpebral fissures, micrognathia, high forehead, low-set ears, telecanthus and corneal(More)