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This paper challenges the view that Grounded Theory is an unacceptable methodology for IS research lacking rigor and robustness. A demonstration is given of the systematic and rigorous use of the grounded theory data analysis techniques in researching the use of commercial IT components for developing and maintaining business IS. The data analysis processes(More)
Highly purified chicken progesterone receptor (cPR) is shown to stimulate RNA synthesis directly in an in vitro transcription assay. Stimulation of transcription by cPR requires the presence of progesterone response elements (PREs) in the template and can be specifically inhibited by addition of competitor oligonucleotides containing PREs. Binding of(More)
The human progesterone receptor form B (hPR-B) was expressed in Saccharomyces cerevisiae together with a specific reporter plasmid. To understand the mechanism underlying antagonist ligand activity, libraries of hormone binding domain (HBD)-mutated hPR-B molecules were prepared. A mutant receptor was identified that had lost the ability to bind either(More)
This paper investigates the effect of mobile phone screen size (1.65 inches-2.75 inches) on video based learning. It first examines the educational benefits of video as a teaching medium and surveys the usage and issues related with video based learning. After which, it investigates the value of video for mobile learning. It reports on an empirical(More)
Deleted in malignant brain tumors 1 (DMBT1) is a candidate suppressor of malignancies of the brain, lung, gut, and breast. We have been studying gene expression in the uterus in the presence of estrogens and their antagonists. Here, we show that DMBT1 RNA levels are robustly increased by estrogen treatment in the uteri of ovariectomized monkeys and rats. In(More)
Estrogen has numerous beneficial physiological actions; however, by acting as a mitogen, it plays a significant role in the induction and maintenance of breast cancer. Although the positive effects of estrogen on gene expression are well described, negative gene regulation is not. Using microarray analysis, we identified 27 genes that were up-regulated and(More)
Agile teams advocates face-to-face conversation, frequent communication and close collaboration between team members in order to work together as one team. In distributed software development, however, separation through space, time and culture affects the ability of the members of a distributed team to work together as one team. Through a Grounded Theory(More)
The tension between software architecture and agility is not well understood by agile practitioners or researchers. If an agile software team spends too little time designing architecture up-front then the team faces increased risk and higher chance of failure; if the team spends too much time the delivery of value to the customer is delayed, and responding(More)
Estrogens have multiple effects on the growth and development of cells in their target tissues, including the uterus, ovary, breast, bone marrow and brain. The hormone regulates the transcription of diverse genes in these tissues via the estrogen receptor, a nuclear transcription factor. Naturally occurring estrogens and estrogen analogs including selective(More)