George Alexopoulos

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BACKGROUND Twenty years have elapsed since the National Institute of Mental Health Collaborative Depression Study reported on the early course and treatment of major depression within the mental health sector. Using similar methods, an observational study was conducted to assess relationships between initial depression severity, personality dysfunction and(More)
A major factor in the context of evaluating depression in the elderly is the role of medical problems. With aging there is a rapid increase in the prevalence of a number of medical disorders, including cancer, heart disease, Parkinson's disease, Alzheimer's disease, stroke, and arthritis. In this article, we hope to bring clarity to the definition of(More)
OBJECTIVE This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old." METHOD This randomized 8-week medication trial compared citalopram, 10-40 mg/day, to placebo in the treatment of patients 75 and older with unipolar depression. RESULTS A total of 174 patients who were 58% women with a mean age of(More)
  • Anna Odom, Peter Chiu, Ba, Nicholas Juul, Dimitry Francois, Nabil Kotbi +1 other
  • 2012
T he patient, a 49-year-old, successful businessman, was first diagnosed with bipolar disorder at the age of 35 years. He underwent trials of combination therapy including lithium, divalproex, venla-faxine, escitalopram, olanzapine, and quetiapine but never achieved full remission; symptoms of dysphoria, irritability, and impulsive behavior remained.(More)
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