Learn More
We present a new method for determining the orientation of alpha-helical sections of proteins or peptides in membrane. To apply this method, membranes containing proteins must be prepared in a multilayer array. Circular dichroism (CD) spectra of the multilayer sample are then measured at the normal as well as oblique incident angles with respect to the(More)
This book probes deep into the science and engineering of methanol production. Its authors include Professor Olah, a 1994 Nobel Prize winner in Chemistry for his work on hydrocarbon chemistry in superacids. If you seek a textbook or an easy to understand technical assessment of methanol, this is the book for you. It contains overviews of oil, natural gas,(More)
We report the first X-ray diffraction on gramicidin in its membrane-active form by using uniformly aligned multilayer samples of membranes containing gramicidin and ions (T1+, K+, Ba2+, Mg2+ or without ions). From the difference electron density profiles, we found a pair of symmetrically located ion-binding sites for T1- at 9.6 (+/- 0.3) A and for Ba2+ at(More)
Easy to prepare solid materials based on fumed silica impregnated with polyethylenimine (PEI) were found to be superior adsorbents for the capture of carbon dioxide directly from air. During the initial hours of the experiments, these adsorbents effectively scrubbed all the CO(2) from the air despite its very low concentration. The effect of moisture on the(More)
Nature's photosynthesis uses the sun's energy with chlorophyll in plants as a catalyst to recycle carbon dioxide and water into new plant life. Only given sufficient geological time, millions of years, can new fossil fuels be formed naturally. The burning of our diminishing fossil fuel reserves is accompanied by large anthropogenic CO(2) release, which is(More)
Small-angle X-ray scattering and Fourier transform infrared (FTIR) spectroscopy experiments have been completed on the catalytic subunit of the cAMP-dependent protein kinase. Measurements were made both with and without the protein kinase inhibitor peptide, PKI alpha(5-22)amide. Binding of the peptide results in an overall contraction of the structure that(More)
Isomeric 1- and 3-isoquinolinols (11 and 12) when activated in CF(3)SO(3)H-SbF(5) acid system undergo selective ionic hydrogenation with cyclohexane to give 5,6,7,8-tetrahydro-1(2H)- and 5,6,7,8-tetrahydro-3(2H)-isoquinolinones (22 and 27). Under the influence of aluminum chloride similar products were also obtained along with 3,4-dihydro-1(2H)- and(More)
A series of silylated carboxonium ions, 2a-6a, were prepared as long-lived species by treating triethylsilane and triphenylmethyl tetrakis(pentafluorophenyl)borate (Ph3C(+)B(C6F5)4-) with ketones, enones, carbonates, amides, and urea in CD2Cl2 solution. They were characterized by 13C and 29Si NMR spectroscopy at -78 degrees C. The NMR study indicates that(More)
Calmodulin (CaM) is the major intracellular receptor for Ca2+ and is responsible for the Ca2+-dependent regulation of a wide variety of cellular processes via interactions with a diverse array of target enzymes. Our current view of the structural basis for CaM enzyme activation is based on biophysical studies of CaM complexed with small peptides that model(More)
Phosphatidylcholine multilayers, containing 20% water by total sample weight and gramicidin/lipid molar ratios up to 1:40 were aligned by low temperature annealing (less than 60 degrees C) and mechanical stressing. We were able to obtain large (greater than 80 micron thick X 40 mm2 area) monodomain defect-free multilayers containing approximately 10(17)(More)