Georg Sebastian Hönes

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Thyroid dysfunction is more common in the female population, however, the impact of sex on disease characteristics has rarely been addressed. Using a murine model, we asked whether sex has an influence on phenotypes, thyroid hormone status, and thyroid hormone tissue response in hyper- and hypothyroidism. Hypo- and hyperthyroidism were induced in(More)
The substrate binding site of pig mitochondrial malate dehydrogenase was characterized using complexes of the enzyme with the substrate analogue 8-hydroxypyrene-1,3,6-trisulfonate with and without the addition of coenzymes. The rotational mobility of the fluorescent dye within the binding site was examined with the aid of a multi-frequency(More)
The coenzyme-binding site in mitochondrial malate dehydrogenase from pig heart was studied using dynamic fluorescence anisotropy decay. The dynamics of the fluorescent ligands NADH and 6-cyano-7-hydroxy-4,8-dimethylcoumarin were used to detect conformational changes at the dihydronicotinamide-and at the adenosine-binding sites, respectively. Addition of the(More)
Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administration to induce chronic hyperthyroidism in(More)
Context Fetuses exposed to the high thyroid hormone (TH) levels of mothers with resistance to thyroid hormone beta (RTHβ), due to mutations in the THRB gene, have low birth weight and suppressed TSH. Objective Determine if such exposure to high TH levels in embryonic life has a long-term effect into adulthood. Design Observations in humans with a(More)
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