Georg Sebastian Hönes

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Context Fetuses exposed to the high thyroid hormone (TH) levels of mothers with resistance to thyroid hormone beta (RTH-β), due to mutations in the THRB gene, have low birth weight and suppressed TSH. Objective Determine if such exposure to high TH levels in embryonic life has a long-term effect into adulthood. Design Observations in humans with a(More)
Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs. oral levothyroxine (T4) administration to induce chronic hyperthyroidism in(More)
The coenzyme-binding site in mitochondrial malate dehydrogenase from pig heart was studied using dynamic fluorescence anisotropy decay. The dynamics of the fluorescent ligands NADH and 6-cyano-7-hydroxy-4,8-dimethylcoumarin were used to detect conformational changes at the dihydronicotinamide-and at the adenosine-binding sites, respectively. Addition of the(More)
Thyroid dysfunction is more common in the female population, however, the impact of sex on disease characteristics has rarely been addressed. Using a murine model, we asked whether sex has an influence on phenotypes, thyroid hormone status, and thyroid hormone tissue response in hyper- and hypothyroidism. Hypo- and hyperthyroidism were induced in(More)
The substrate binding site of pig mitochondrial malate dehydrogenase was characterized using complexes of the enzyme with the substrate analogue 8-hydroxypyrene-1,3,6-trisulfonate with and without the addition of coenzymes. The rotational mobility of the fluorescent dye within the binding site was examined with the aid of a multi-frequency(More)
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